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SJA6017

化学構造式
190274-53-4
CAS番号.
190274-53-4
化学名:
别名:
英語名:
SJA6017
英語别名:
SJA6017;Calpain-In-4;Calpain Inhibitor 4;CALPAIN INHIBITOR VI;4-FLUORO-BENZENESULFONYL-VAL-L-LEUCINAL;4-FLUORO-BENZENESULFONYL-VAL-LEU-ALDEHYDE;N-(4-FLUOROPHENYLSULFONYL)-L-VALYL-L-LEUCINAL;SJA6017, 4-Fluoro-benzenesulfonyl-Val-L-leucinal;Calpain Inhibitor VI 4-Fluoro-benzenesulfonyl-Val-Leu-aldehyde;Butanamide, 2-[[(4-fluorophenyl)sulfonyl]amino]-N-[(1S)-1-formyl-3-methylbutyl]-3-methyl-, (2S)-
CBNumber:
CB6427018
化学式:
C17H25FN2O4S
分子量:
372.45
MOL File:
190274-53-4.mol

SJA6017 物理性質

比重(密度) :
1.185±0.06 g/cm3(Predicted)
貯蔵温度 :
Store at -20°C
溶解性:
DMSO: 5 mg/ml
外見 :
A lyophilized solid
酸解離定数(Pka):
9.04±0.50(Predicted)

安全性情報

SJA6017 価格 もっと(2)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01BCS4043024
Calpain Inhibitor VI, 4-Fluoro-benzenesulfonyl-Val-Leu-aldehyde 		190274-53-4 1mg ￥41000 2020-09-21 購入
富士フイルム和光純薬株式会社(wako) W01BCS4043024
Calpain Inhibitor VI, 4-Fluoro-benzenesulfonyl-Val-Leu-aldehyde 		190274-53-4 5mg ￥166000 2020-09-21 購入

SJA6017 化学特性,用途語,生産方法

説明

Calpain inhibitor VI is an inhibitor of the calcium-dependent cysteine proteases μ-calpain (calpain-1; IC50 = 7.5 nM) and m-calpain (calpain-2; IC50 = 78 nM). It also inhibits cathepsins B and L (IC50s = 15 and 1.6 nM, respectively). It is selective for these calpains and cathepsins over other cysteine and serine proteases, factor VIIa, factor Xa, trypsin, chymotrypsin, and proteasome. In an in vitro porcine model of cataract, calpain inhibitor VI decreases the degree of cataract by 40% when used at a concentration of 0.8 μM. It also prevents cataract formation induced by selenite in rats when administered at a dose of 100 mg/kg for 4 days. Calpain inhibitor VI improves functional outcome and reduces apoptotic cell death in a rat model of spinal cord injury.

SJA6017 上流と下流の製品情報

原材料

準備製品

SJA6017 生産企業

Global( 41)Suppliers
名前 電話番号 電子メール 国籍 製品カタログ 優位度
Alpha Biopharmaceuticals Co., Ltd 		+86-411-39042497 +8613921981412
 sales@alphabiopharm.com China 886 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 19892 58
Nextpeptide Inc 		+86-0571-81612335 +8613336028439
 sales@nextpeptide.com China 19915 58
Nanjing TGpeptide 		+86-13347807150 +86-13347807150
 support@tgpeptide.com China 3279 58
Aladdin Scientific 		+1-833-552-7181
sales@aladdinsci.com United States 52927 58
Alabiochem Tech.Co., Ltd. 0512-58900862 400-0707518
 sales@alabiochem.com China 995 59
GL Biochem (Shanghai) Ltd 21-61263452 13641803416
 ymbetter@glbiochem.com China 9981 64
VDM Biochemicals 0330-2528181
sales@vdmbio.com United States 510 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696;
 info@hanhongsci.com China 42982 64
Chemsky (shanghai) International Co.,Ltd 021-50135380
shchemsky@sina.com China 15421 60
  • 190274-53-4
  • N-(4-FLUOROPHENYLSULFONYL)-L-VALYL-L-LEUCINAL
  • 4-FLUORO-BENZENESULFONYL-VAL-LEU-ALDEHYDE
  • 4-FLUORO-BENZENESULFONYL-VAL-L-LEUCINAL
  • CALPAIN INHIBITOR VI
  • SJA6017, 4-Fluoro-benzenesulfonyl-Val-L-leucinal
  • SJA6017
  • Calpain Inhibitor VI 4-Fluoro-benzenesulfonyl-Val-Leu-aldehyde
  • Calpain Inhibitor 4
  • Calpain-In-4
  • Butanamide, 2-[[(4-fluorophenyl)sulfonyl]amino]-N-[(1S)-1-formyl-3-methylbutyl]-3-methyl-, (2S)-
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