チロシジン 化学特性,用途語,生産方法
解説
チロシジン,Aの塩酸塩は融点204～242 ℃．[α]D－111°(50％ エタノール)．水に易溶，メタノールに微溶．いずれもグラム陽性菌および陰性菌に有効で，細胞質膜に作用して透過性を乱す．毒性はマウス最小致死量5 mg/kg(静脈)．
製造
グラミシジンとともに，枯草菌Bacillus brevisの培養液から得られる環状ペプチド抗菌性物質の混合物．A，B，Cの3種類が知られている．
化学的特性
White or almost white powder.
使用
Tyrothricin is a complex of two unrelated peptide families, gramicidin complex and tyrocidines complex, produced by Bacillus brevis and discovered by Dubos in 1939. Typically, tyrothricin is composed of 20% of the linear pentadecylpeptide gramicidins and 80% of cyclic decapeptide tyrocidines. Both the gramicidins and tyrocidines act by disrupting bacterial cell wall integrity, but by differing mechanisms. Tyrothricin is used clinically for bacterial skin infections in some countries.
定義
An antibiotic produced by growth of Bacillus brevis. It consists of a mixture of antibiotics, principally gramicidin and tyrocidine. Gramicidin is the more active component. Use is generally limited to local external applications. It is active against some Gram-positive bacteria, including species of pneumococci, streptococci, and staphylococci.
チロシジン 上流と下流の製品情報
原材料
準備製品