N-[4-[4-(2-メトキシフェニル)-1-ピペラジニル]ブチル]-2-ナフタレンカルボアミド

N-[4-[4-(2-メトキシフェニル)-1-ピペラジニル]ブチル]-2-ナフタレンカルボアミド 価格 もっと(1)

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入
Sigma-Aldrich Japan	B9308	>98% (HPLC), solid BP897 >98% (HPLC), solid	314776-92-6	5mg	￥22300	2024-03-01	購入

N-[4-[4-(2-メトキシフェニル)-1-ピペラジニル]ブチル]-2-ナフタレンカルボアミド 化学特性,用途語,生産方法

説明

BP-897 is a dopamine D₃ receptor partial agonist. It selectively binds to the dopamine D₃ over the D₂, D₁, and D₄ receptors (K_is = 0.92, 61, 3,000, and 300 nM, respectively, for the recombinant human receptors). It is also selective over α₁- and α₂-adrenergic receptors (K_is = 60 and 83 nM, respectively) and the serotonin (5-HT) receptor subtypes 5-HT_1A and 5-HT₇ (K_is = 84 and 345 nM, respectively), as well as muscarinic, histamine, and opioid receptors (K_is = >1 μM for all). BP-897 inhibits cAMP accumulation induced by forskolin (EC₅₀ = 1 nM) and increases mitogenesis in NG 108-15 cells with a maximum efficacy of 55%, an effect that can be blocked by the dopamine D₃ receptor antagonist nafadotride. It also acts as a dopamine D₃ receptor antagonist, failing to increase [³⁵S]GTPγS binding to CHO cell membranes expressing the recombinant human D₃ receptor and inhibiting the effect of dopamine in the same assay (IC₅₀ = 416.87 nM). BP-897 (0.5 and 1 mg/kg) reduces cocaine-seeking behavior, but has no reinforcing properties itself, in rats trained to self-administer cocaine.

Biochem/physiol Actions

Partially selective D3 dopamine receptor agonist.

N-[4-[4-(2-メトキシフェニル)-1-ピペラジニル]ブチル]-2-ナフタレンカルボアミド 上流と下流の製品情報

原材料

準備製品

N-[4-[4-(2-メトキシフェニル)-1-ピペラジニル]ブチル]-2-ナフタレンカルボアミド 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131981	58
Tianjin Derchemist Science & Technology Co., Ltd.	22-58627059 13920586291	zdcomcon@126.com	China	2918	50
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.	025-66099280 17798518460	cfzhang@aikonchem.com	China	19918	55
Wuhan Kaymke Chemical Co., Ltd.,	027-87342388 18086026008	sales@kaymke.com	China	4123	55
AdooQ BioScience, LLC	+1 (866) 930-6790	info@adooq.com	United States	2784	58

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• 314776-92-6
• BP897/BP-897
• N-[4-[4-(2-Methoxyphenyl)-1-piperazinyl]butyl]-2-naphthalenecarboxamide monohydrochloride
• N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]naphthalene-2-carboxamide
• BP897 >98% (HPLC), solid
• N-(4-(4-(2-Methoxyphenyl)piperazin-1-yl)butyl)-2-naphthamide hydrochloride
• BP 897 (hydrochloride)
• Inhibitor,inhibit,stimuli,BP-897,behaviour,Dopamine Receptor,BP 897 hydrochloride,addiction,rewarding,BP 897,cocaine drug-seeking,motivational,BP897
• N-{4-[4-(2-メトキシフェニル)ピペラジン-1-イル]ブチル}ナフタレン-2-カルボキサミド
• N-[4-[4-(2-メトキシフェニル)-1-ピペラジニル]ブチル]-2-ナフタレンカルボアミド