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CGI 1746

CGI 1746 化学構造式
910232-84-7
CAS番号.
910232-84-7
化学名:
CGI 1746
别名:
CGI 1746;N-[2-メチル-3-[1-メチル-5-[[4-(モルホリノカルボニル)フェニル]アミノ]-6-オキソ-1,6-ジヒドロピラジン-3-イル]フェニル]-4-tert-ブチルベンズアミド;4-tert-ブチル-N-[2-メチル-3-(4-メチル-6-{[4-(モルホリン-4-カルボニル)フェニル]アミノ}-5-オキソ-4,5-ジヒドロピラジン-2-イル)フェニル]ベンズアミド
英語名:
N-[3-[4,5-Dihydro-4-methyl-6-[[4-(4-morpholinylcarbonyl)phenyl]amino]-5-oxo-2-pyrazinyl]-2-methylphenyl]-4-(tert-butyl)benzamide
英語别名:
G-182;GCI1746;CS-1389;CGI-1746;CGI-1746, >98%;CGI-1746/CGI1746;CGI-1746;CGI1746;CGI 1746;CGI 1746 (This product is only available in Japan.);N-[3-[4,5-Dihydro-4-methyl-6-[[4-(4-morpholinylcarbonyl)phenyl]amino]-5-oxo-2-pyrazinyl]-2-met;4-tert-butyl-N-[2-methyl-3-[4-methyl-6-[4-(morpholine-4-carbonyl)anilino]-5-oxopyrazin-2-yl]phenyl]benzamide
CBNumber:
CB82521185
化学式:
C34H37N5O4
分子量:
579.69
MOL File:
910232-84-7.mol

CGI 1746 物理性質

比重(密度) :
1.22
貯蔵温度 :
Store at -20°C
溶解性:
≥29 mg/mL in DMSO; insoluble in H2O; ≥6.72 mg/mL in EtOH with gentle warming and ultrasonic
外見 :
solid

安全性情報

CGI 1746 価格 もっと(2)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
東京化成工業 C3586 CGI 1746 >96.0%(HPLC)
CGI 1746 (This product is only available in Japan.) >96.0%(HPLC)		 910232-84-7 10mg ￥11900 2024-03-01 購入
東京化成工業 C3586 CGI 1746 >96.0%(HPLC)
CGI 1746 (This product is only available in Japan.) >96.0%(HPLC)		 910232-84-7 50mg ￥38900 2024-03-01 購入

CGI 1746 化学特性,用途語,生産方法

説明

CGI1746 is a potent, selective inhibitor of Bruton’s tyrosine kinase (BTK; IC50 = 1.9 nM), a non-receptor tyrosine kinase that is important in B lymphocyte development. It blocks both auto-and trans-phosphorylation of BTK by occupying an SH3 binding pocket in the un-phosphorylated enzyme. CGI1746 prevents B-cell antigen receptor-mediated B lymphocyte proliferation and suppresses FCγRIII-induced TNFα, IL-1β, and IL-6 production in macrophages. It reduces cytokine levels within joints and ameliorates symptoms in a mouse model of autoantibody-induced arthritis.

使用

CGI 1746 is a Bruton’s tyrosine kinase (Btk) inhibitor to be used in antitumor drugs.

CGI 1746 上流と下流の製品情報

原材料

準備製品

CGI 1746 生産企業

Global( 106)Suppliers
名前 電話番号 電子メール 国籍 製品カタログ 優位度
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32480 60
career henan chemical co 		+86-0371-86658258
sales@coreychem.com China 29914 58
Biochempartner 		0086-13720134139
candy@biochempartner.com CHINA 967 58
Hubei xin bonus chemical co. LTD 		86-13657291602
linda@hubeijusheng.com CHINA 22968 58
BOC Sciences 		+1-631-485-4226
inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd 		+86-023-61398051 +8613650506873
 sales@chemdad.com China 39916 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427
 sales@conier.com China 49390 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 19892 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250
 1026@dideu.com China 29220 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471
 sales@sarms4muscle.com China 10523 58

CGI 1746  スペクトルデータ(1HNMR)

N-[3-[4,5-Dihydro-4-methyl-6-[[4-(4-morpholinylcarbonyl)phenyl]amino]-5-oxo-2-pyrazinyl]-2-methylphenyl]-4-(tert-butyl)benzamide(910232-84-7)1HNMR

910232-84-7(CGI 1746)キーワード:

Y-27632二塩酸塩 サラカチニブ レゴラフェニブ スペブルチニブ ダクトリシブ
  • 910232-84-7
  • N-[3-[4,5-Dihydro-4-methyl-6-[[4-(4-morpholinylcarbonyl)phenyl]amino]-5-oxo-2-pyrazinyl]-2-methylphenyl]-4-(tert-butyl)benzamide
  • GCI1746
  • CGI-1746;CGI1746;CGI 1746
  • N-[3-[4,5-Dihydro-4-methyl-6-[[4-(4-morpholinylcarbonyl)phenyl]amino]-5-oxo-2-pyrazinyl]-2-met
  • CGI-1746
  • G-182
  • CGI-1746/CGI1746
  • N-[3-[4,5-dihydro-4-methyl-6-[[4-(4-morpholinylcarbonyl)phenyl]amino]-5-oxopyrazinyl]-2-methylphenyl]-4-(1,1-dimethylethyl)-benzamide
  • N-[3-[4,5-Dihydro-4-methyl-6-[[4-(4-morpholinylcarbonyl)phenyl]amino]-5-oxo-2-pyrazinyl]-2-methylphenyl]-4-(tert-butyl)benzamide CGI-1746
  • 4-tert-butyl-N-(2-methyl-3-(4-methyl-6-(4-(morpholine-4-carbonyl)phenylamino)-5-oxo-4,5-dihydropyrazin-2-yl)phenyl)benzamide
  • 4-tert-butyl-N-[2-methyl-3-[4-methyl-6-[4-(morpholine-4-carbonyl)anilino]-5-oxopyrazin-2-yl]phenyl]benzamide
  • CGI-1746, >98%
  • CS-1389
  • CGI 1746 (This product is only available in Japan.)
  • Benzamide, N-[3-[4,5-dihydro-4-methyl-6-[[4-(4-morpholinylcarbonyl)phenyl]amino]-5-oxo-2-pyrazinyl]-2-methylphenyl]-4-(1,1-dimethylethyl)-
  • N-[3-[4,5-Dihydro-4-methyl-6-[[4-(4-morpholinylcarbonyl)phenyl]amino]-5-oxo-2-pyrazinyl]-2-methylphenyl]-4-(tert-butyl)benzamide USP/EP/BP
  • CGI 1746
  • N-[2-メチル-3-[1-メチル-5-[[4-(モルホリノカルボニル)フェニル]アミノ]-6-オキソ-1,6-ジヒドロピラジン-3-イル]フェニル]-4-tert-ブチルベンズアミド
  • 4-tert-ブチル-N-[2-メチル-3-(4-メチル-6-{[4-(モルホリン-4-カルボニル)フェニル]アミノ}-5-オキソ-4,5-ジヒドロピラジン-2-イル)フェニル]ベンズアミド
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