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3-[[2-[[3-(モルホリン-4-イル)プロピル]アミノ]ピリミジン-4-イル]アミノ]-9-エチル-9H-カルバゾール

3-[[2-[[3-(モルホリン-4-イル)プロピル]アミノ]ピリミジン-4-イル]アミノ]-9-エチル-9H-カルバゾール 化学構造式
1380432-32-5
CAS番号.
1380432-32-5
化学名:
3-[[2-[[3-(モルホリン-4-イル)プロピル]アミノ]ピリミジン-4-イル]アミノ]-9-エチル-9H-カルバゾール
别名:
N4-(9-エチル-9H-カルバゾール-3-イル)-N2-[3-(モルホリン-4-イル)プロピル]ピリミジン-2,4-ジアミン;3-[[2-[[3-(モルホリン-4-イル)プロピル]アミノ]ピリミジン-4-イル]アミノ]-9-エチル-9H-カルバゾール
英語名:
N4-(9-Ethyl-9H-carbazol-3-yl)-N2-(3-Morpholin-4-yl-propyl)-pyriMidine-2,4-diaMine
英語别名:
EHop-016;EHop-016, >=98%;EHOP 016;EHOP016;EHOP016; EHOP-016; EHOP 016; EHOP016; EHOP-016; EHOP 016.;N4-(9-Ethyl-9H-carbazol-3-yl)-N2-(3-morpholinopropyl)pyrimidine-2,4-diamine;4-N-(9-ethylcarbazol-3-yl)-2-N-(3-morpholin-4-ylpropyl)pyrimidine-2,4-diamine;N4-(9-Ethyl-9H-carbazol-3-yl)-N2-[3-(4-morpholinyl)propyl]-2,4-pyrimidinediamine;N4-(9-Ethyl-9H-carbazol-3-yl)-N2-(3-Morpholin-4-yl-propyl)-pyriMidine-2,4-diaMine;2,4-Pyrimidinediamine, N4-(9-ethyl-9H-carbazol-3-yl)-N2-[3-(4-morpholinyl)propyl]-;N4-(9-Ethyl-9H-carbazol-3-yl)-N2-[3-(4-morpholinyl)propyl]-2,4-pyrimidinediamine Ehop-016
CBNumber:
CB82631369
化学式:
C25H30N6O
分子量:
430.55
MOL File:
1380432-32-5.mol
MSDS File:
SDS

3-[[2-[[3-(モルホリン-4-イル)プロピル]アミノ]ピリミジン-4-イル]アミノ]-9-エチル-9H-カルバゾール 物理性質

沸点 :
633.9±65.0 °C(Predicted)
比重(密度) :
1.27
貯蔵温度 :
2-8°C
溶解性:
DMSO：可溶10mg/mL、透明
酸解離定数(Pka):
7.30±0.10(Predicted)
外見 :
粉
色:
白からベージュ

安全性情報

WGK Germany  3

3-[[2-[[3-(モルホリン-4-イル)プロピル]アミノ]ピリミジン-4-イル]アミノ]-9-エチル-9H-カルバゾール 価格 もっと(2)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
Sigma-Aldrich Japan SML0526 ≥98% (HPLC)
EHop-016 ≥98% (HPLC)		 1380432-32-5 5mg ￥21600 2024-03-01 購入
Sigma-Aldrich Japan SML0526 ≥98% (HPLC)
EHop-016 ≥98% (HPLC)		 1380432-32-5 25mg ￥80900 2024-03-01 購入

3-[[2-[[3-(モルホリン-4-イル)プロピル]アミノ]ピリミジン-4-イル]アミノ]-9-エチル-9H-カルバゾール 化学特性,用途語,生産方法

説明

EHop-016 is an inhibitor of the small Rho GTPases Rac1 and Rac3. It inhibits Rac1 activity in MDA-MB-435 breast cancer cells with an IC50 value of 1.1 μM in a Rac1 activation assay. At a concentration of 1 μM, EHop-016 inhibits 58% of Rac3 activity, and it inhibits Cdc42 activity but only at higher concentrations (5-10 μM). It also increases Rho GTPase RhoA activity ~1.3-fold at concentrations greater than 2 μM. EHop-016 (2-4 μM) inhibits Rac-regulated functions in MDA-MB-435 cells, including lamellipodia formation and serine/threonine p21-activated kinase 1 (PAK1)-mediated cell migration. In a nude mouse model of breast cancer metastasis, EHop-016 (25 mg/kg) significantly lowers mammary fat pad tumor growth, metastasis, and angiogenesis. It also inhibits mutant receptor tyrosine kinase (KIT)-induced growth in systemic mastocytosis and acute myeloid leukemia (AML) cells (≥2.5 μM).

使用

EHop-016 has been used as the EHop inhibitor to study signalling diversity during Chlamydia trachomatis cell entry. It has also been used as a RAC inhibitor.

Biochem/physiol Actions

EHop-016 is a potent and specific inhibitor of Rac1 and Rac3 GTPase activity that inhibits Vav2 interaction with Rac, Rac-activated PAK1, lamellipodia formation, and cell migration. EHop-016 inhibits the Rac activity of MDA-MB-231 metastatic breast cancer cells and reduces Rac-directed lamellipodia formation.

3-[[2-[[3-(モルホリン-4-イル)プロピル]アミノ]ピリミジン-4-イル]アミノ]-9-エチル-9H-カルバゾール 上流と下流の製品情報

原材料

N-(3-アミノプロピル)モルホリン 3-アミノ-N-エチルカルバゾール

準備製品

3-[[2-[[3-(モルホリン-4-イル)プロピル]アミノ]ピリミジン-4-イル]アミノ]-9-エチル-9H-カルバゾール 生産企業

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3-[[2-[[3-(モルホリン-4-イル)プロピル]アミノ]ピリミジン-4-イル]アミノ]-9-エチル-9H-カルバゾール  スペクトルデータ(1HNMR)

N4-(9-Ethyl-9H-carbazol-3-yl)-N2-(3-Morpholin-4-yl-propyl)-pyriMidine-2,4-diaMine(1380432-32-5)1HNMR

1380432-32-5(3-[[2-[[3-(モルホリン-4-イル)プロピル]アミノ]ピリミジン-4-イル]アミノ]-9-エチル-9H-カルバゾール)キーワード:

Mdivi-1 ZCL278 Y-27632二塩酸塩 NSC23766 EHT1864 (-)-ラパマイシン
  • 1380432-32-5
  • EHop-016
  • EHOP-016;N4-(9-ETHYL-9H-CARBAZOL-3-YL)-N2-(3-MORPHOLIN-4-YL-PROPYL)-PYRIMIDINE-2,4-DIAMINE
  • N4-(9-Ethyl-9H-carbazol-3-yl)-N2-(3-Morpholin-4-yl-propyl)-pyriMidine-2,4-diaMine
  • N4-(9-Ethyl-9H-carbazol-3-yl)-N2-[3-(4-morpholinyl)propyl]-2,4-pyrimidinediamine
  • N4-(9-Ethyl-9H-carbazol-3-yl)-N2-[3-(4-morpholinyl)propyl]-2,4-pyrimidinediamine Ehop-016
  • EHop-016, >=98%
  • EHOP016; EHOP-016; EHOP 016; EHOP016; EHOP-016; EHOP 016.
  • EHOP 016;EHOP016
  • 4-N-(9-ethylcarbazol-3-yl)-2-N-(3-morpholin-4-ylpropyl)pyrimidine-2,4-diamine
  • 2,4-Pyrimidinediamine, N4-(9-ethyl-9H-carbazol-3-yl)-N2-[3-(4-morpholinyl)propyl]-
  • N4-(9-Ethyl-9H-carbazol-3-yl)-N2-(3-Morpholin-4-yl-propyl)-pyriMidine-2,4-diaMine USP/EP/BP
  • N4-(9-Ethyl-9H-carbazol-3-yl)-N2-(3-morpholinopropyl)pyrimidine-2,4-diamine
  • N4-(9-エチル-9H-カルバゾール-3-イル)-N2-[3-(モルホリン-4-イル)プロピル]ピリミジン-2,4-ジアミン
  • 3-[[2-[[3-(モルホリン-4-イル)プロピル]アミノ]ピリミジン-4-イル]アミノ]-9-エチル-9H-カルバゾール
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