NSC23766
NSC23766 物理性質
- 融点 :
- >225°C (dec.)
- 貯蔵温度 :
- -20°C
- 溶解性:
- H2O: 可溶10mg/mL、透明
- 外見 :
- 粉
- 色:
- 白からベージュ
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01TOC2161 |
NSC23766
NSC 23766 |
1177865-17-6 |
10mg |
￥58000 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01TOC2161 |
NSC23766
NSC 23766 |
1177865-17-6 |
50mg |
￥247000 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
SML0952 |
≥97% (HPLC)
NSC23766 trihydrochloride ≥97% (HPLC) |
1177865-17-6 |
5mg |
￥29200 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
SML0952 |
≥97% (HPLC)
NSC23766 trihydrochloride ≥97% (HPLC) |
1177865-17-6 |
25mg |
￥92700 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01W0118-0320 |
Rac1阻害剤 98.0+%(HPLC)
Rac1 Inhibitor 98.0+%(HPLC) |
1177865-17-6 |
5mg |
￥23100 |
2024-03-01 |
購入 |
NSC23766 化学特性,用途語,生産方法
外観
白色～ほとんど白色、結晶～粉末
溶解性
水及びエタノールに溶け、アセトンにほとんど溶けない。
使用上の注意
不活性ガス封入
説明
Rac1 is a GTPase that is involved in the regulation of the cell cycle, cell-
cell adhesion, motility, and differentiation. Rac1 is activated by its interaction with specific guanine nucleotide exchange factors (GEFs). NSC 23766 is a cell-
permeable, reversible inhibitor of Rac1 activation by the Rac-
specific GEFs TrioN and Tiam 1 (IC
50 = 50 μM). It has no effect on the closely related GTPases, Cdc42 and RhoA. NSC23766 has been used to investigate the role of Rac1 in such diverse cellular functions as stem cell mobilization, epithelial cell migration, angiogenesis, leukemia cell migration and growth, and gene expression.
使用
NSC 23766 is a highly soluble and membrane permeable Rac GTPase inhibitor. NSC 23766 inhibits Rac GTPase by targeting Rac activation by guanine nucleotide exchange factor (GEF). NSC 23766 has been shown to inhibit the anchorage-independent growth and invasion phenotypes of human prostate cancer PC-3 cells.
Biochem/physiol Actions
NSC23766 is an inhibitor of Rac1, a Rho-family GTPase. The compound blocks activation by the guanine nucleotide exchange factors Trio and Tiam1, but does not affect interactions with RhoA or Cdc42. NSC23766 blocks ADP-mediated platelet aggregation. Inhibition of Rac1 by NSC23766 restores sensitivity to trastuzumab by restoring down-regulation of ErbB2.
NSC23766 上流と下流の製品情報
原材料
準備製品
NSC23766 生産企業
Global( 73)Suppliers
1177865-17-6(NSC23766)キーワード:
- 1177865-17-6
- NSC 23766 (hydrochloride)
- NSC 23766 (trihydrochloride)
- NSC23766 trihydrochloride
- NSC-23766 trihydrochloride
- N6-[2-(4-Diethylamino-1-methyl-butylamino)-6-methyl-pyrimidin-4-yl]-2-methyl-quinoline-4,6-diamine trihydrochloride
- NSC-23766 HCl
- NSC 23766, >=98%
- Rac1 Inhibitor
- NSC 23766; NSC23766;NSC-23766 TRIHYDROCHLORIDE;NSC23766 TRIHYDROCHLORIDE
- NSC 23766;NSC23766;NSC-23766
- N6-[2-[[4-(Diethylamino)-1-methylbutyl]amino]-6-methyl-4-pyrimidinyl]-2-methyl-4,6-quinolinediamine trihydrochloride
- Rac1 Inhibitor - CAS 1177865-17-6 - Calbiochem
- NSC-23766 3HCl
- NSC 23766 (hydrochloride) USP/EP/BP
- Inhibitor,Ras,inhibit,Apoptosis,NSC 23766 trihydrochloride
- NSC23766
- RAC1阻害剤