1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine

1228780-72-0

CAS番号.: 1228780-72-0

化学名:

别名:

英語名:: 1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine

英語别名:: Abt199 int3;Venetoclax Intermediate 1;1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl...;1-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]piperazine;1-((2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-enyl)methyl)piperazine;(4-(2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-enyl)methyl)piperazine;1-[[2-(4-chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]Piperazine;Piperazine, 1-[[2-(4-chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]-;"1-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1- en-1-yl]methyl}piperazine" ;1-((4'-Chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methy)piperazine

CBNumber:: CB82742388

化学式:: C19H27ClN2

分子量:: 318.88

MOL File:: 1228780-72-0.mol

物理性質

安全性情報

価格8

用途語

生産企業 184

1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine 物理性質

沸点 :: 421.2±45.0 °C(Predicted)

比重(密度) :: 1.072±0.06 g/cm3(Predicted)

貯蔵温度 :: under inert gas (nitrogen or Argon) at 2–8 °C

酸解離定数(Pka):: 9.21±0.10(Predicted)

安全性情報

リスクと安全性に関する声明
危険有害性情報のコード(GHS)

絵表示（GHS）

注意喚起語

警告

危険有害性情報

コード	危険有害性情報	危険有害性クラス	区分	注意喚起語	P コード
H302	飲み込むと有害	急性毒性、経口	4	警告	P264, P270, P301+P312, P330, P501
H315	皮膚刺激	皮膚腐食性/刺激性	2	警告	P264, P280, P302+P352, P321,P332+P313, P362
H319	強い眼刺激	眼に対する重篤な損傷性/眼刺激性	2A	警告	P264, P280, P305+P351+P338,P337+P313P
H335	呼吸器への刺激のおそれ	特定標的臓器毒性、単回暴露；気道刺激性	3	警告

注意書き

P261	粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避けること。
P305+P351+P338	眼に入った場合：水で数分間注意深く洗うこと。次にコンタクトレンズを着用していて容易に外せる場合は外すこと。その後も洗浄を続けること。

1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine 価格もっと(8)

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入
富士フイルム和光純薬株式会社(wako)	W01COBQE-9973	1-([2-(4-Chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl)piperazine dihydrochloride salt	1228780-72-0	25g	￥47500	2024-03-01	購入
富士フイルム和光純薬株式会社(wako)	W01COBQE-9973	1-([2-(4-Chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl)piperazine dihydrochloride salt	1228780-72-0	10g	￥44600	2023-06-01	購入
富士フイルム和光純薬株式会社(wako)	W01COBQE-9973	1-([2-(4-Chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl)piperazine dihydrochloride salt	1228780-72-0	1g	￥10000	2024-03-01	購入
富士フイルム和光純薬株式会社(wako)	W01COBQE-9973	1-([2-(4-Chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl)piperazine dihydrochloride salt	1228780-72-0	5g	￥16500	2024-03-01	購入
富士フイルム和光純薬株式会社(wako)	W01FLC504674	1-([2-(4-CHLOROPHENYL)-4,4-DIMETHYLCYCLOHEX-1-EN-1-YL]METHYL)PIPERAZINE 2HCL SALT	1228780-72-0	25g	￥87800	2018-12-26	購入

1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine 化学特性,用途語,生産方法

使用

1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine is an intermediate of Venetoclax (ABT-199) which is a small, oral chemical molecule used for the treatment of chronic lymphocytic leukemia (CLL) associated with a specific chromosomal abnormality.

1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine 上流と下流の製品情報

原材料

Methyl 2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-ene-1-carboxylate 4,4-ジメチル-2-オキソシクロヘキサンカルボン酸メチル 3,3-ジメチルシクロヘキサノン (2-(4-クロロフェニル)-4,4-ジメチルシクロヘキス-1-エニル)メタノール 2-クロロ-4,4-ジメチルシクロヘキス-1-エンカルブアルデヒド tert-butyl 4-((4'-chloro-5,5-diMethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)Methyl)piperazine-1-carboxylate Methyl 4,4-dimethyl-2-[(trifluoromethylsulfonyl)oxy]cyclohex-1-ene-1-carboxylate 4'-chloro-5,5-diMethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-carbaldehyde 2-(4-クロロフェニル)-4,4,5,5-テトラメチル-1,3,2-ジオキサボロランピペラジン 4-クロロフェニルボロン酸 4-クロロヨードベンゼン

準備製品

Methyl 2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]-4-[4-[[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-enyl]methyl]piperazin-1-yl]benzoate 2-((1H-Pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoic acid

1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine 生産企業

Global( 184)Suppliers

名前	電話番号	電子メール	国籍	製品カタログ	優位度
Hangzhou ICH Biofarm Co., Ltd	+undefined8613073685410	sales@ichemie.com	China	985	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1811	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
Shanghai Yingrui Biopharma Co., Ltd.	+86-21-33585366 - 03@	sales03@shyrchem.com	CHINA	738	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Nanjing Dolon Biotechnology Co.,Ltd.	18905173768	sales@dolonchem.com	CHINA	2972	58
Hangzhou Cyanochem Co., Ltd.	+86 17788583750	sales@cyanochem.com	CHINA	283	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58

1228780-72-0()キーワード:

1-(トリイソプロピルシリル)-1H-ピロロ[2,3-B]ピリジン-5-オールベネトクラクス 2-(1H-ピロロ[2,3-B]ピリジン-5-イルオキシ)-4-フルオロ安息香酸メチル 3-ニトロ-4-((テトラヒドロ-2H-ピラン-4-イル)メチルアミノ)ベンゼンスルホンアミド

1228780-72-0
1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine
1-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazine dihydrochloride salt
1-((2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-enyl)methyl)piperazine
Abt199 int3
1-[[2-(4-chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]Piperazine
"1-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1- en-1-yl]methyl}piperazine"
1-((4'-Chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methy)piperazine
Piperazine, 1-[[2-(4-chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]-
1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl...
1-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]piperazine
Venetoclax Intermediate 1
(4-(2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-enyl)methyl)piperazine
1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine