4-Hydroxy ThalidoMide
4-Hydroxy ThalidoMide 物理性質
- 融点 :
- 273-275 °C
- 沸点 :
- 568.3±45.0 °C(Predicted)
- 比重(密度) :
- 1.611±0.06 g/cm3(Predicted)
- 貯蔵温度 :
- under inert gas (nitrogen or Argon) at 2-8°C
- 溶解性:
- DMF: 12 mg/ml; DMSO: 10 mg/ml
- 外見 :
- A solid
- 酸解離定数(Pka):
- 6.82±0.20(Predicted)
- InChI:
- InChI=1S/C13H10N2O5/c16-8-3-1-2-6-10(8)13(20)15(12(6)19)7-4-5-9(17)14-11(7)18/h1-3,7,16H,4-5H2,(H,14,17,18)
- InChIKey:
- XMPJICVFSDYOEG-UHFFFAOYSA-N
- SMILES:
- C1(=O)C2=C(C(O)=CC=C2)C(=O)N1C1CCC(=O)NC1=O
4-Hydroxy ThalidoMide 価格
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4-Hydroxy ThalidoMide 化学特性,用途語,生産方法
使用
2-(2,6-Dioxopiperidin-3-yl)-4-hydroxyisoindoline-1,3-dione is an intermediate for the synthesis of dTAG-13 (D710020), which is a degradation tag which was tested for its efficiency at depleting FKBP12F36V -MELK(sg3R) and was found to have significantly degraded FKBP12F36V -MELK(sg3R) within 4 hours.Used in the study of cancer research.
参考文献
[1] M. G. Marks. “Effects of putative hydroxylated thalidomide metabolites on blood vessel density in the chorioallantoic membrane (CAM) assay and on tumor and endothelial cell proliferation.” Biological & pharmaceutical bulletin 356 1 (2002): 597–604.
4-Hydroxy ThalidoMide 上流と下流の製品情報
原材料
準備製品
4-Hydroxy ThalidoMide 生産企業
Global( 142)Suppliers
5054-59-1()キーワード:
- 5054-59-1
- 4-Hydroxy ThalidoMide
- 2-(2,6-Dioxo-piperidin-3-yl)-4-hydroxy-isoindole-1,3-dione
- 2-(2,6-dioxopiperidin-3-yl)-4-hydroxy-2,3-dihydro-1H-isoindole-1,3-dione
- E3 ligase Ligand 2
- Pomalidomide Impurity 15
- Thalidomide Impurity 1
- 186942
- 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-hydroxy-
- Thalidomide 4-Hydroxy Impurity
- 4-hydroxy-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
- 2-(2,6-dioxo-piperidine-3-yl)-4-hydroxy-isoindole-1,3-dione
- Thalidomide-4-OH
- 2-(2,6-Dioxo-3-piperidinyl)-4-hydroxyisoindoline-1,3-dione
- 2-(2,6-dioxopiperidin-3-yl)-4-hydroxyisoindoline-1,3-dione
- Cereblon ligand 2
- 2-(2,6-dioxo-3-piperidyl)-4-hydroxy-isoindoline-1,3-dione