2-ethoxyethyl N-(4-(3-methyl-5-isoxazolyl)-2-thiazolyl)oxamate
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2-ethoxyethyl N-(4-(3-methyl-5-isoxazolyl)-2-thiazolyl)oxamate 속성
안전
2-ethoxyethyl N-(4-(3-methyl-5-isoxazolyl)-2-thiazolyl)oxamate C화학적 특성, 용도, 생산
Originator
Asobamast,Onbio Inc.Manufacturing Process
1). 179 mmol of bromine in 20 ml of chloroform were added dropwise in 10 minutes to a solution of 172 mmol of 3-methyl-5-acetylisoxazole, (Gass. Chim. Ital. 72, 242, 194) containing 4.9 ml of glacial acetic acid while the reaction mixture was maintained under stirring at 48°-50°C. After 5 minutes the mixture was poured into 300 g of water and crushed ice. The organic layer was separated, washed with water, dried and evaporated to residual 3- methyl-5-bromoacetylisoxazole. Yield 87%, white crystalline compound, MP: 44°-46°C (isopropyl ether).2). A mixture of 50 mmol of 3-methyl-5-bromoacetylisoxazole and 100 mmol of thiourea in 164 ml of ethyl alcohol was refluxed for 90 minutes and then cooled for 1 hour with an ice bath. The precipitate was collected by filtration and added to a mixture of 25 ml of a 10% aqueous solution of sodium hydroxide and 100 ml of ethyl acetate under vigorous stirring. The organic layer was separated, washed, dried and evaporated to dryness after recrystallization from acetonitrile the 2-amino-4-(3-methyl-5- isoxazolyl)thiazole melts at 208°-210°C. Yield, 57%.
3). To a mixture of 20.5 mmol of 2-amino-4-(3-methyl-5-isoxazolyl)thiazole in 37.4 ml of pyridine maintained under stirring at 5°C were added dropwise 23.6 mmol of 2-ethoxyethyloxalyl chloride. The reaction mixture was maintained under stirring overnight, then poured into 100 g of crushed ice, made acid with concentrate hydrochloric acid and extracted with chloroform. The chloroform extracts were washed with water, dried and evaporated to dryness. The residual 2-ethoxyethyl-4-(3-methyl-5-isoxazolyl)thiazole-2- oxamate was re-crystallized from 65 ml of acetonitrile. Yield, 91%, MP: 155°- 156°C.
Therapeutic Function
Antiallergic, Anti-asthmatic2-ethoxyethyl N-(4-(3-methyl-5-isoxazolyl)-2-thiazolyl)oxamate 준비 용품 및 원자재
원자재
준비 용품
2-ethoxyethyl N-(4-(3-methyl-5-isoxazolyl)-2-thiazolyl)oxamate 공급 업체
글로벌( 2)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 |
support@targetmol.com | United States | 19973 | 58 |
Shanghai Dexuan Pharmaceutical Technology Co., Ltd | 1701086315 |
dexuanpharma@126.com | China | 9478 | 58 |