5-FLUORO-2-METHYL-3-NITRO-BENZOICACID메틸에스테르
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5-FLUORO-2-METHYL-3-NITRO-BENZOICACID메틸에스테르 속성
- 끓는 점
- 297.7±40.0 °C(Predicted)
- 밀도
- 1.335±0.06 g/cm3(Predicted)
- 저장 조건
- Sealed in dry,Room Temperature
- 용해도
- Slightly soluble in water. Soluble in dimethyl sulfoxide and acetone.
- 색상
- 하얀색
안전
HS 번호 | 2916399090 |
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5-FLUORO-2-METHYL-3-NITRO-BENZOICACID메틸에스테르 C화학적 특성, 용도, 생산
용도
Methyl 5-fluoro-2-methyl-3-nitrobenzoate is used in organic synthesis and it is used in the synthesis of 6-Fluoro-4-nitroisobenzofuran-1 (3H)-one.제조 방법
Methyl 5-fluoro-2-methyl-3-nitrobenzoate synthesis: To a solution of conc. H2SO4 (700mL) was added portionwise 5-fluoro-2-methylbenzoic acid (80g, 520 mmol) at -5-0°C. Then a mixture of conc. HNO3(60.4 g. 624 mmol) in conc. H2SO4 (60 mL) was added drop-wise at -5-0°C. in a period of about 1.5 hrs. After the addition, the mixture was stirred at this temperature for 2 hrs. TLC (petroleum ether/ EtOAc=1:1) showed the reaction was complete. The mixture was poured into crash ice with vigorous stirring and the precipitate was collected by filtration. The precipitate was dissolved in EtOAc, washed with brine, dried over anhydrous Na2SO4 concentrated to give crude 5-fluoro-2-methyl-3-nitrobenzoic acid (54 g). A solution of this crude 5-fluoro-2-methyl-3-nitrobenzoic acid (54 g) in dry methanol (500 mL) was cooled to 0°C., SOCl2 (64.52g, 542.3 mmol) was added drop-wise. After the addition, the mixture was heated to reflux for 16hrs. TLC (petroleum ether/EtOAc=1:1) showed the reaction was complete. Solvent was removed under reduced pressure to give crude product. The crude product was purified by silica gel chromatography (petroleum ether to petro leum ether/EtOAc=50: 1) to give methyl 5-fluoro-2-methyl-3-nitrobenzoate (28 g, yield 25% for two steps) as a white solid.5-FLUORO-2-METHYL-3-NITRO-BENZOICACID메틸에스테르 준비 용품 및 원자재
원자재
준비 용품
5-FLUORO-2-METHYL-3-NITRO-BENZOICACID메틸에스테르 공급 업체
글로벌( 167)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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Zhejiang Karry Pharmachem Co., Ltd. | +8613567161161 |
info@karrypharma.com | China | 34 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29798 | 60 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 |
sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ |
sales03@shyrchem.com | CHINA | 738 | 60 |
Fluoropharm Co., Ltd. | +86-0571-85586753; +8613336034509 |
sales@fluoropharm.com | China | 1377 | 60 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32836 | 60 |
Anqing Chico Pharmaceutical Co., Ltd. | 15380796838 |
chloewu@chicopharm.cn | CHINA | 341 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29888 | 58 |
Zhejiang ZETian Fine Chemicals Co. LTD | +8618957127338 |
stella@zetchem.com | China | 2136 | 58 |
Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 |
sales@ansciepchem.com | CHINA | 4242 | 58 |
5-FLUORO-2-METHYL-3-NITRO-BENZOICACID메틸에스테르 관련 검색:
Methyl 5-fluoro-2-(MethylaMino)benzoate
Methyl 5-fluoro-2-iodobenzoate
METHYL 5-FLUORO-2-HYDROXYBENZOATE
Dimethyl carbonate
5-Formylimidazole-4-carboxylic acid methyl ester
Methyl 5-formylpyrrole-3-carboxylate
Methyl 5-fluoro-6-Methoxy-1H-indole-2-carboxylate
5-FLUORO-2-METHOXYBENZALDEHYDE
5-FLUORO-2-METHOXYACETOPHENONE
5-Fluoro-2-methoxyphenol
5-Fluoro-2-methoxyphenyl acetic acid
5-FLUORO-2-METHOXYBENZONITRILE
5-Fluoro-2-methylbenzoic acid
METHYL 2-METHYL-5-FLUOROBENZOATE