Human Chondrocytes - Osteoarthritis: HC-OA, adult

Human Chondrocytes - Osteoarthritis: HC-OA, adult C화학적 특성, 용도, 생산

용도

model for studying chondrocyte biology in an osteoarthritis joint

일반 설명

HC-OA Human Chondrocytes are derived from human articular cartilage of donors with osteoarthritis (OA). Osteoarthritis is an inflammatory disease characterized by increased degradation of cartilage tissue in the joint due to overproduction of enzymes degrading the extracellular matrix. Despite the initial proliferation and activation of chondrocytes, they are not able to efficiently repair the degrading cartilage. Instead, chondrocytes undergo terminal differentiation and eventually apoptose, leading to mineralization of cartilage in a process resembling bone formation during development. Thus, HC-OA provide a useful model to study changes in chondrocyte biology in response to abnormal environment of the OA joint.

Characterization: Positive for aggrecan after differentiation.

HC-OA have been used to demonstrate that THF-alpha activates transcription of ADAMTS-4, a metalloproteinase implicated in cartilage degradation in OA, via p38-MAPK-dependent mechanism (Xue, 2013).

Human Chondrocytes - Osteoarthritis: HC-OA, adult 준비 용품 및 원자재

원자재

준비 용품

Human Chondrocytes - Osteoarthritis: HC-OA, adult 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80