4-(N-나이트로소메틸아미노)-1-(3-피리딜)-1-뷰타논
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4-(N-나이트로소메틸아미노)-1-(3-피리딜)-1-뷰타논 속성
- 녹는점
- 63-65°C
- 끓는 점
- 346.25°C (rough estimate)
- 밀도
- 1.1933 (rough estimate)
- 굴절률
- 1.4830 (estimate)
- 인화점
- 9℃
- 저장 조건
- Amber Vial, -20°C Freezer
- 용해도
- DMF: 30 mg/ml, DMSO: 25 mg/ml, Ethanol: 25 mg/ml,
- 산도 계수 (pKa)
- 3.19±0.10(Predicted)
- 물리적 상태
- Solid
- 색상
- White to light yellow
- BRN
- 3548355
- 안정성
- 안정적인. 강한 산화제와 호환되지 않습니다.
- InChI
- InChI=1S/C10H13N3O2/c1-13(12-15)7-3-5-10(14)9-4-2-6-11-8-9/h2,4,6,8H,3,5,7H2,1H3
- InChIKey
- FLAQQSHRLBFIEZ-UHFFFAOYSA-N
- SMILES
- C(C1=CC=CN=C1)(=O)CCCN(C)N=O
- CAS 데이터베이스
- 64091-91-4
- IARC
- 1 (Vol. Sup 7, 89, 100E) 2012
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn,T,F | ||
---|---|---|---|
위험 카페고리 넘버 | 26/27/28-45-43-40-22-39/23/24/25-23/24/25-11 | ||
안전지침서 | 45-53-36/37-16 | ||
유엔번호(UN No.) | 2811 | ||
WGK 독일 | 3 | ||
RTECS 번호 | OB6465000 | ||
위험 등급 | 6.1 | ||
포장분류 | II | ||
HS 번호 | 38220090 | ||
유해 물질 데이터 | 64091-91-4(Hazardous Substances Data) | ||
독성 | LD50 intraperitoneal in mouse: 1gm/kg | ||
중점관리물질 필터링 | 별표2-376 |
4-(N-나이트로소메틸아미노)-1-(3-피리딜)-1-뷰타논 C화학적 특성, 용도, 생산
화학적 성질
Off-White Crystals용도
This compound was present in the highest concentrations in smokeless tobacco out of the nitrosamines identified. Readily produces cancer in rats and hamsters생산 방법
NNK is not produced commercially. NNK is formed by oxidation and nitrosation of nicotine and is produced during the curing, aging, processing, and smoking of tobacco. NNK has been found in tobacco at levels up to 35 mg/kg, in snuff up to 8.3 mg/kg, and in cigarette smoke up to 0.5 mg per cigarette (179, 193). Common cigarette filters considerably reduce the amount of NNK that reaches the smoker. NNK is extracted from snuff by the saliva of users, and as much as 0.2 μg/g of saliva has been measured. Potential exposure to NNK is widespread also among those exposed to sidestream smoke and has been detected at 0.2–15.7 μg/ cigarette. Evidence from one comparative study of tobacco-specific nitrosamines in cigarettes suggests that levels of NNK (measured as a sum of all tobacco-specific nitrosamines) are higher in non-Moldovan cigarette tobacco and Moldovan blended cigarettes, suggesting that current tobacco production and manufacturing technologies may create conditions that favor N-nitrosation of alkaloids and other tobacco constituents.일반 설명
Pale yellow crystalline solid.공기와 물의 반응
4-(N-NITROSOMETHYLAMINO)-1-(3-PYRIDYL)-1-BUTANONE may be sensitive to prolonged exposure to air and light.반응 프로필
A nitrated amine and ketone. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. Ketones are reactive with many acids and bases liberating heat and flammable gases (e.g., H2). The amount of heat may be sufficient to start a fire in the unreacted portion of the ketone. Ketones react with reducing agents such as hydrides, alkali metals, and nitrides to produce flammable gas (H2) and heat. Ketones are incompatible with isocyanates, aldehydes, cyanides, peroxides, and anhydrides. They react violently with aldehydes, HNO3, HNO3 + H2O2, and HClO4.화재위험
Flash point data for 4-(N-NITROSOMETHYLAMINO)-1-(3-PYRIDYL)-1-BUTANONE are not available; however, 4-(N-NITROSOMETHYLAMINO)-1-(3-PYRIDYL)-1-BUTANONE is probably combustible.Safety Profile
Confirmed carcinogen with experimental carcinogenic and neoplastigenic data. An experimental teratogen. Mutation data reported. A flammable liquid. When heated to decomposition it emits toxic fumes of NOx.Carcinogenicity
4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone (NNK) is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.4-(N-나이트로소메틸아미노)-1-(3-피리딜)-1-뷰타논 준비 용품 및 원자재
원자재
준비 용품
4-(N-나이트로소메틸아미노)-1-(3-피리딜)-1-뷰타논 공급 업체
글로벌( 97)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 |
757984502@qq.com | China | 892 | 58 |
Accela ChemBio Inc. | +1-858-6993322 |
info@accelachem.com | United States | 19536 | 58 |
Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 |
contact@fuxinpharm.com | China | 10297 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 |
1026@dideu.com | China | 8672 | 58 |
Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 |
masar@topule.com | China | 8474 | 58 |
LEAPCHEM CO., LTD. | +86-852-30606658 |
market18@leapchem.com | China | 43348 | 58 |
Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 |
product@acmec-e.com | China | 33350 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 |
sales@aladdinsci.com | United States | 57511 | 58 |
Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 |
orders@jknbiochem.com | China | 5225 | 58 |
4-(N-나이트로소메틸아미노)-1-(3-피리딜)-1-뷰타논 관련 검색:
4-(N-나이트로소메틸아미노)-1-(3-피리딜)-1-뷰타논
4-(N-METHYL-N-NITROSOAMINO)-1-(3-PYRIDYL-D4)-1-BUTANONE
4-(carbethoxynitrosamino)-1-(3-pyridyl)-1-butanone
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone N-b-D-Glucuronide
4-(Acetoxymethyl)nitrosamino]-1-(3-pyridyl)-1-butanone
4-(Methylnitrosamino)-1-(3-pyridyl-N-oxide)-1-butanone
NNK-d3, 4-(Methyl-d3-nitrosoamino)-1-(3-pyridinyl)-1-butanone
2-HYDROXYIMINO-4-METHYLNITROSAMINO-1-(3-PYRIDYL)-1-BUTANONE
(RS)-4-(N-METHYL-N-NITROSAMINO)-1-(3-PYRIDYL)-1-BUTANONE, [PYRIDYL-5-3H]-