Phosphatidylinositol 4,5-bisphosphate C화학적 특성, 용도, 생산
효소 저해제
Thes membrane phospholipids, differing only in the fatty acyl components linked to C1 and C2 of the glycerol moiety, also called triphosphoinositides and abbreviated PIP2 or PI-4,5-P2, are important intermediates in a metabolic scheme that generates effectors for a number of metabolic processes. Phosphatidylinositol 4,5-bisphosphate is a precursor to the intracellular messengers inositol 1,4,5-trisphosphate and sn-1,2- diacylglycerol. Phosphatidylinositol 4,5-bisphosphate is an essential cofactor and stimulator of phospholipase D and is a substrate for specific isoforms of phospholipase C. See specific compound Note: The free acid slowly decomposes whereas the sodium salt can be stored cold in chloroform for extended periods. The stearoyl arachidonyl form (i.e., 1’- stearoyl-2’-arachidonoyl-sn-glycerol-3-phospho-1D-myo-inositol 4,5- bisphosphate, shown above) is a form commonly found in mammals. Target(s): [b-adrenergic-receptor] kinase; AMP deaminase; arachidonoyl-diacylglycerol kinase, a specific diacylglycerol kinase; casein kinase I; caspase 8; caspase 9; ER-60 protease; glucose-6-phosphatase; nitric-oxide synthase; phosphatidate cytidylyltransferase; 1-phosphatidylinositol 4-kinase; 1- phosphatidylinositol-4-phosphate 5-kinase, product inhibition; protein kinase C; protein-tyrosine kinase; and sphingomyelin phosphodiesterase, or sphingomyelinase.
