3-(1-Methylethyl)-6-(phenylMethyl)-2(1H)-pyrazinone

3-(1-Methylethyl)-6-(phenylMethyl)-2(1H)-pyrazinone 구조식 이미지
카스 번호:
170713-71-0
상품명:
3-(1-Methylethyl)-6-(phenylMethyl)-2(1H)-pyrazinone
동의어(영문):
Aureusimine B;6-BENZYL-3-ISOPROPYLPYRAZIN-2-ONE;6-benzyl-3-isopropylpyrazin-2(1H)-one;3-(1-Methylethyl)-6-(phenylMethyl)-2(1H)-pyrazinone;2(1H)-Pyrazinone, 3-(1-methylethyl)-6-(phenylmethyl)-
CBNumber:
CB12682115
분자식:
C14H16N2O
포뮬러 무게:
228.28964
MOL 파일:
170713-71-0.mol

3-(1-Methylethyl)-6-(phenylMethyl)-2(1H)-pyrazinone 속성

녹는점
117-118 °C
밀도
1.10±0.1 g/cm3(Predicted)
저장 조건
Refrigerator
용해도
클로로포름(약간 용해됨), 메탄올(약간 용해됨)
물리적 상태
고체
물리적 상태
단단한 모양
산도 계수 (pKa)
11.65±0.60(Predicted)
색상
미색에서 밝은 회색까지

안전

3-(1-Methylethyl)-6-(phenylMethyl)-2(1H)-pyrazinone C화학적 특성, 용도, 생산

개요

Aureusimine B, also known as phevalin, is a natural pyrazinone produced by certain fungi and by Staphylococcus spp., including S. aureus. Its synthesis appears to be initiated by a conserved nonribosomal peptide synthetase that creates a dipeptide (phenylalanine-valine) aldehyde, which then undergoes cyclization and oxidation. Aureusimine B inhibits calpain in a casein hydrolysis assay (IC50 = 1.3 μM), contributes to S. aureus infection in mice, and alters human keratinocyte gene expression.

용도

Aureusimine B is a novel small molecule isolated from S. aureus as one of a pair of related metabolites controversially identified as virulence factors in the pathology of Golden Staph. Aureusimine B has also been reported as an inhibitor of the protease, calpain.

3-(1-Methylethyl)-6-(phenylMethyl)-2(1H)-pyrazinone 준비 용품 및 원자재

원자재

준비 용품


3-(1-Methylethyl)-6-(phenylMethyl)-2(1H)-pyrazinone 공급 업체

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