Anti-PD-L2;Anti-B7-DC;Anti-PD-1-ligand 2;Anti-CD273 antigen;Anti-PDCD1 ligand 2;Anti-Butyrophilin B7-DC;Anti-Programmed death ligand 2;Anti-Programmed death ligand 1;Anti-Programmed cell death 1 ligand-2;Anti-PDL-2 antibody produced in rabbit
Anti-PDL-2 antibody produced in rabbit has been used in immunohistochemistry.
일반 설명
Programmed cell death 1 ligand 2 (PD-L2 or PDCD1 ligand 2) is also known as butyrophilin B7-DC or CD273. It belongs to the immunoglobulin superfamily. The gene encoding PDL-2 is localized on human chromosome 9p24.1.
Biochem/physiol Actions
The expression of programmed cell death 1 ligand 2 (PD-L2) or CD antigen 273 (CD273) is up-regulated by interferon-γ (IFNG/IFN-γ) stimulation in monocytes and induced on dendritic cells grown from peripheral blood mononuclear cells with colony-stimulating factor-2 (CSF2) and interleukin-4 (IL-4). PD-L2 is involved in the co-stimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. PD-L2 interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.
