R-IMPP

R-IMPP 구조식 이미지
카스 번호:
2133832-83-2
상품명:
R-IMPP
동의어(영문):
R-IMPP;PF-00932239 (R-IMPP);Benzenepropanamide, N-1-isoquinolinyl-4-methoxy-N-(3R)-3-piperidinyl-;(R)-N-(Isoquinolin-1-yl)-3-(4-methoxyphenyl)-N-(piperidin-3-yl)propanamide;Serine endopeptidases,PF-00932239,PF 00932239,inhibit,Ser/Thr Protease,RIMPP,R-IMPP,Inhibitor,Threonine proteases,R IMPP,PF00932239,Serine proteases
CBNumber:
CB13155117
분자식:
C24H27N3O2
포뮬러 무게:
389.49
MOL 파일:
2133832-83-2.mol

R-IMPP 속성

끓는 점
594.4±50.0 °C(Predicted)
밀도
1.186±0.06 g/cm3(Predicted)
저장 조건
Store at -20°C
용해도
DMF: 1 mg/ml; DMSO: 10 mg/ml
물리적 상태
결정성 고체
산도 계수 (pKa)
9.14±0.10(Predicted)
색상
Light yellow to yellow

안전

R-IMPP C화학적 특성, 용도, 생산

개요

(R)-IMPP is a cell-permeable inhibitor of the secretion of proprotein convertase subtilisin/kexin type 9 (PCSK9; IC50 = 4.8 μM). It promotes the uptake of LDL cholesterol in hepatoma cells by increasing LDL receptor levels. (R)-IMPP apparently impairs PCSK9 secretion by causing transcript-dependent inhibition of PCSK9 translation.

R-IMPP 준비 용품 및 원자재

원자재

준비 용품


R-IMPP 공급 업체

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