6-Iodo-1H-indazole
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6-Iodo-1H-indazole 속성
- 녹는점
- 207.0 to 211.0 °C
- 끓는 점
- 358.2±15.0 °C(Predicted)
- 밀도
- 2.082±0.06 g/cm3(Predicted)
- 저장 조건
- under inert gas (nitrogen or Argon) at 2–8 °C
- 용해도
- DMSO(약간 용해됨), 메탄올(약간 용해됨)
- 산도 계수 (pKa)
- 12.96±0.40(Predicted)
- 물리적 상태
- 액체
- 색상
- 무색투명~연황색
- InChI
- InChI=1S/C7H5IN2/c8-6-2-1-5-4-9-10-7(5)3-6/h1-4H,(H,9,10)
- InChIKey
- RSGAXJZKQDNFEP-UHFFFAOYSA-N
- SMILES
- N1C2=C(C=CC(I)=C2)C=N1
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
HS 번호 | 29339980 |
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6-Iodo-1H-indazole C화학적 특성, 용도, 생산
용도
6-Iodo-1H-indazole is an intermediate used to synthesize inhibitors of Chk1.Synthesis
Revill P. and co-worker synthesized Axitinib by iodination of 6-iodo-1H-indazole (100) to give 3,6-di iodo- 1H-indazole (101) ,which on further reaction with 2- mercapto-N-methylbenzenesulfinamide gives 2-(3-iodo-1Hindazol-6-ylthio)-N-methylbenzamide (101), the same can be obtained via 2-(1H-indazol-6-ylthion)-N-methylbenzamide (102) starting from 6-iodo-1H-indazole (100) through alternative route. N-protection of 2-(3-iodo-1H-indazol-6- ylthio)-N-methylbenzamide (101) by Boc2, DMAP or DHP, TsOH gives respective N-protected intermediates 103, 104. Further treatment of 103, 104 with 2-vinyl pyridine give rise to N-protected-2-(1-methyl-3-(2-(pyridine-2-yl) vinyl)-1Hindazole-6-ylthio) benzothioamide 105 and 106. Deprotection of 105 and 106 gives destination compound axitinib (107), the same can be obtained without protection from 2-(3-iodo-1H-indazol-6-ylthio)-N-methylbenzamide (101) by simple reaction with 2-vinyl pyridine[1].6-Iodo-1H-indazole 준비 용품 및 원자재
원자재
준비 용품
6-Iodo-1H-indazole 공급 업체
글로벌( 277)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Zison Pharmaceutical (Shandong) Co., Ltd. | +86-0086-531-88259693 +86-18660188356 |
tracy.li@zisonpharm.com | China | 57 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 |
sales@hbmojin.com | China | 12446 | 58 |
Henan Bao Enluo International TradeCo.,LTD | +86-17331933971 +86-17331933971 |
deasea125996@gmail.com | China | 2503 | 58 |
Jinan Million Pharmaceutical Co., Ltd | 0531-68659554 +8613031714605 |
info@millionpharm.com | China | 206 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 20291 | 58 |
Hebei Mojin Biotechnology Co.,Ltd | +86-15028179902 |
angelia@hbmojin.com | China | 1085 | 58 |
Hebei Ganmiao New material Technology Co., LTD | +86-17332992504 +86-17332992504 |
sales8@hbganmiao.com | China | 300 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29798 | 60 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21667 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32836 | 60 |
6-Iodo-1H-indazole 관련 검색:
6-Iodo-1H-indazole
4-IODO (1H)INDAZOLE
3-Iodo-6-nitroindazole
4-Fluoro-3-iodo-1H-indazole
5-BROMO-3-IODO (1H)INDAZOLE
1H-INDAZOLE, 3-BROMO-7-IODO-
5-Fluoro-3-iodo-1H-indazole
5-CHLORO-3-IODO-1H-INDAZOLE
5-Iodo-1H-indazole
3-Amino-4-iodo-1H-indazole
3-BROMO-6-IODO (1H)INDAZOLE
3-HYDROXY-6-IODO (1H)INDAZOLE
3,6-DIIODO-4-METHYL (1H)INDAZOLE
4,6-DIIODO-1H-INDAZOLE
6-IODO-3-(1H)INDAZOLE CARBOXYLIC ACID
6-IODO-3-(1H)INDAZOLE CARBOXALDEHYDE
4-AMINO-3-HYDROXY-6-IODO-1H-INDAZOLE
6-IODO-4-METHYL (1H)INDAZOLE