Anti-SMC6L1, Anti-Structural maintenance of chromosome 6, Anti-Structural maintenance of chromosomes 6-like 1

Anti-SMC6L1, Anti-Structural maintenance of chromosome 6, Anti-Structural maintenance of chromosomes 6-like 1 구조식 이미지
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상품명:
Anti-SMC6L1, Anti-Structural maintenance of chromosome 6, Anti-Structural maintenance of chromosomes 6-like 1
동의어(영문):
SMC6;SMC6L1;FLJ35534;FLJ22116;Anti-SMC6L1;Anti-SMC6 antibody produced in rabbit;Anti-structural maintenance of chromosome 6;Anti-Structural maintenance of chromosomes 6-like 1;Anti-SMC6L1, Anti-Structural maintenance of chromosome 6, Anti-Structural maintenance of chromosomes 6-like 1
CBNumber:
CB22089203
분자식:
포뮬러 무게:
0
MOL 파일:
Mol file

Anti-SMC6L1, Anti-Structural maintenance of chromosome 6, Anti-Structural maintenance of chromosomes 6-like 1 속성

저장 조건
-20°C

안전

Anti-SMC6L1, Anti-Structural maintenance of chromosome 6, Anti-Structural maintenance of chromosomes 6-like 1 C화학적 특성, 용도, 생산

용도

Suggested starting dilutions are as follows: ICC/IF: 1:100-1:1000, IHC-P: 1:100-1:1000, WB: 1:500-1:3000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.

일반 설명

Structural maintenance of chromosomes protein 6 (SCM6) belongs to the structural maintenance of chromosomes family. There are at least six SMC family members that form three heterodimers in specific combinations. SCM6 gene is mapped to human chromosome 2p24.2. Structurally, SCM6 has DNA-binding domains at the N and C termini, a long coiled-coil domain, and a hinge region.

Biochem/physiol Actions

Structural maintenance of chromosomes protein 6 (SCM6) along with SMC5 is mainly involved in the cellular response to DNA damage in yeast as well as humans. The yeast SMC5/6 complex contains several non-SMC elements (NSE), including methyl methanesulfonate-sensitivity protein 21 (MMS21) which sumoylates components of the complex. The SMC5/6 complex is recruited to nuclease-induced double strand breaks(DSBs). This event is crucial for human SMC1/3 cohesion complex recruitment to DSBs. SCM6 is known to interact with the papillomavirus E2 protein. Mitotic aberration and abnormal distribution of topoisomerase IIα are associated with depleted levels of Smc5 and Smc6.

Anti-SMC6L1, Anti-Structural maintenance of chromosome 6, Anti-Structural maintenance of chromosomes 6-like 1 준비 용품 및 원자재

원자재

준비 용품


Anti-SMC6L1, Anti-Structural maintenance of chromosome 6, Anti-Structural maintenance of chromosomes 6-like 1 공급 업체

글로벌( 7)공급 업체
공급자 전화 이메일 국가 제품 수 이점
Sigma-Aldrich 021-61415566 800-8193336
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