PF 750

PF 750 구조식 이미지
카스 번호:
959151-50-9
상품명:
PF 750
동의어(영문):
PF 750;N-Phenyl-4-(3-quinolinylmethyl)-1-piperidinecarboxamide;N-Phenyl-4-(quinolin-3-ylMethyl)piperidine-1-carboxaMide;1-PiperidinecarboxaMide, N-phenyl-4-(3-quinolinylMethyl)-
CBNumber:
CB22511241
분자식:
C22H23N3O
포뮬러 무게:
345.44
MOL 파일:
959151-50-9.mol

PF 750 속성

끓는 점
582.7±32.0 °C(Predicted)
밀도
1.226
저장 조건
Store at RT
용해도
DMSO: >10mg/mL
산도 계수 (pKa)
14.15±0.70(Predicted)
물리적 상태
결정성 고체
색상
흰색에서 황백색까지
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xn
위험 카페고리 넘버 22
WGK 독일 3
그림문자(GHS): GHS hazard pictograms
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H302 삼키면 유해함 급성 독성 물질 - 경구 구분 4 경고 GHS hazard pictograms P264, P270, P301+P312, P330, P501
예방조치문구:
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
NFPA 704
0
2 0

PF 750 C화학적 특성, 용도, 생산

개요

Fatty acid amide hydrolase (FAAH) is the enzyme responsible for hydrolysis and inactivation of fatty acid amides including anandamide and oleamide. PF-750 is a potent, time-dependent, irreversible FAAH inhibitor with IC50 values of 0.6 and 0.016 μM when preincubated with recombinant human FAAH for 5 and 60 minutes, respectively. Activity-based profiling of various human and murine tissue proteome samples revealed that PF-750 is highly selective for FAAH relative to other serine hydrolases, showing no discernable off-site activity up to 500 μM.

용도

Fatty acid amide hydrolase (FAAH) inhibitor, selectively inhibiting FAAH within the central nervous system

Biochem/physiol Actions

PF-750 is a potent, time-dependent, irreversible FAAH inhibitor with IC50 values 0.6 and 0.016 μM when preincubated with recombinant human FAAH for 5 and 60 minutes, respectively. Fatty acid amide hydrolase (FAAH) is the enzyme responsible for hydrolysis and inactivation of fatty acid amides including anandamide and oleamide. Activity-based profiling of various human and murine tissue proteome samples revealed that PF-750 is highly selective for FAAH relative to other serine hydrolases, showing no discernable off-site activity up to 500 μM. PF-750 shows 10-fold better potency than URB597 (Sigma# U4133) after 30 min preincubation. PF-750 is highly selective on FAAH. Even at as high as 500 μM, it had no interactions with many tested enzymes, but URB597 and other known FAAH inhibitors did not perform well at low concentraction (100 μM).

PF 750 준비 용품 및 원자재

원자재

준비 용품


PF 750 공급 업체

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