GLIOTOXIN
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GLIOTOXIN 속성
- 녹는점
- 221°C (rough estimate)
- 끓는 점
- 699.7±55.0 °C(Predicted)
- 알파
- D25 -290° (c = 0.08 in ethanol)
- 밀도
- 1.4069 (rough estimate)
- 굴절률
- 1.6510 (estimate)
- 인화점
- 2℃
- 저장 조건
- 2-8°C
- 용해도
- 클로로포름: 10mg/mL, 투명, 무색
- 물리적 상태
- 흰색 고체
- 산도 계수 (pKa)
- 12.90±0.40(Predicted)
- 색상
- MeOH 로부터 단사 결정체를 얻는다
- Merck
- 13,4454
- BRN
- 50675
- 안정성
- 공급된 대로 2년 동안 안정적입니다. DMSO의 솔루션은 -20°C에서 최대 1개월 동안 보관할 수 있습니다.
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | T,Xn,F | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 25-36-20/21/22-11 | ||
| 안전지침서 | 36/37/39-45-36/37-16 | ||
| 유엔번호(UN No.) | UN 3462 6.1/PG 3 | ||
| WGK 독일 | 3 | ||
| RTECS 번호 | KB4725000 | ||
| F 고인화성물질 | 4.2-10-23 | ||
| 위험 등급 | 6.1(b) | ||
| 포장분류 | III | ||
| HS 번호 | 29419090 | ||
| 독성 | LD50 oral in mouse: 67mg/kg |
GLIOTOXIN C화학적 특성, 용도, 생산
화학적 성질
White powder용도
Gliotoxin is a sulfur-containing mycotoxin produced by species of fungi and pathogens of humans. Gliotoxin exhibits inhibitory activities against histone H3K9 methyltransferase, a key enzyme in the re gulation of transcriptional activity by writing epigenetic marks. Gliotoxin also exhibits immunosuppressive properties by causing apoptosis of cells of the immune system. In addition, various studies suggests Gliotoxin may also be a potential anti-inflammatory, antibiotic, antifungal and antiviral agent.정의
ChEBI: A pyrazinoindole with a disulfide bridge spanning a dioxo-substituted pyrazine ring; mycotoxin produced by several species of fungi.위험도
Poison.생물학적 활성
Immunosuppressive agent; blocks phagocytosis, cytokine production and proliferation of T and B cells. Non-competitively inhibits chymotrypsin-like activity of 20S proteasome; prevents degradation of I κ B α , an endogenous blocker of NF- κ B. Also inhibits farnesyltransferase and geranylgeranyltransferase I (IC 50 values are 80 and 17 μ M respectively) and displays antitumor activity against breast cancer in vivo .Safety Profile
Poison by intraperitoneal andintravenous routes. When heated to decomposition itemits very toxic fumes such as SOx and NOx.Purification Methods
Purify gliotoxin by recrystallisation from MeOH. Its solubility in CHCl3 is 1%. The dibenzoyl derivative has m 202o (from CHCl3/MeOH). [Glister & Williams Nature 153 651 1944, Elvidge & Spring J Chem Soc Suppl 135 1949, Johnson et al. J Am Chem Soc 65 2005 1943, Bracken & Raistrick Biochem J 41 569 1947.]GLIOTOXIN 준비 용품 및 원자재
원자재
준비 용품
GLIOTOXIN 공급 업체
글로벌( 122)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32480 | 60 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 |
scglp@glp-china.com | CHINA | 1824 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 |
sales@biopurify.com | China | 3424 | 58 |
| Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 |
sales@pioneerbiotech.com | China | 3000 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; |
factory@coreychem.com | China | 29826 | 58 |
| BOC Sciences | +16314854226 |
inquiry@bocsci.com | United States | 19743 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 |
support@targetmol.com | United States | 19973 | 58 |
| ZHEJIANG JIUZHOU CHEM CO., LTD | +86-0576225566889 +86-13454675544 |
admin@jiuzhou-chem.com；jamie@jiuzhou-chem.com；alice@jiuzhou-chem.com | China | 20000 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 |
product@acmec-e.com | China | 33349 | 58 |
| Shaanxi Cuikang Pharmaceutical Technology Co., Ltd | +86-19164747840 +86-13119157289 |
13119157289@163.com | China | 2971 | 58 |
GLIOTOXIN 관련 검색:
디이소프로필에틸렌디아민 2,5-디메틸피페라진 1,3-시클로헥사디엔
(R)-(-)-1-OCTEN-3-OL, 99
BUTYL ETHYL DISULPHIDE
1,5-HEXADIEN-3-OL
1-ALLYLPIPERAZINE
2-Piperazinone
CYCLO(-ALA-ALA)
1,2,4-TRIMETHYLDIETHYLENEDIAMINE
N,N'-Diisopropylethylenediamine
isopropyl methyl disulphide
METHYL PENTYL DISULPHIDE
(S)-(+)-2-Methylpiperazine
CYCLO(-ALA-GLY)
1-ISOPROPYL-PIPERAZIN-2-ONE
(+/-)-1,4-DIAZABICYCLO[4.4.0]DECANE
1-(3-PENTYL)-PIPERAZINE