Ritipenem

Ritipenem 구조식 이미지
카스 번호:
84845-57-8
상품명:
Ritipenem
동의어(영문):
Ritipenem;RITIPENEM ACOXIL;Ritipenem USP/EP/BP;4-Thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 3-[[(aminocarbonyl)oxy]methyl]-6-[(1R)-1-hydroxyethyl]-7-oxo-, (5R,6S)-
CBNumber:
CB2875749
분자식:
C10H12N2O6S
포뮬러 무게:
288.28
MOL 파일:
84845-57-8.mol

Ritipenem 속성

안전

Ritipenem C화학적 특성, 용도, 생산

개요

Ritipenem is a synthetic b-lactam antibiotic of the penem class that has a broad antimicrobial spectrum and high resistance to b-lactamases. Since it is stable in relation to renal dehydropeptidase-I, ritipenem does not require concomitant administration of an inhibitor of this enzyme.

용도

Ritipenem is a penem antibiotic.

Mechanism of action

In common with other b-lactams, ritipenem interacts with the penicillin-binding proteins (PBPs). In E. coli, the main target of ritipenem is PBP2, and PBP3 is also equivalent to PBP2 in the Enterobacteriaceae. In vitro studies suggest that ritipenem has affinity for the PBP2 of methicillin-susceptible S. aureus and PBP2u of methicillin-resistant S. aureus.

Clinical Use

Ritipenem has been used in a limited number of clinical conditions in which the use of a carbapenem that can be administered both parenterally and orally was considered a possible advantage. Ritipenem is not currently licensed for clinical use by the US FDA. Only a few clinical studies have assessed the role of ritipenem therapy, and these have been in the treatment of respiratory tract or urinary tract infections, but results appear generally disappointing.

Toxicology

In an Italian study, 8 of 15 (53%) chronic obstructive pulmonary disease (COPD) patients treated with 3.0 g of ritipenem acoxil developed mild to severe gastrointestinal complaints (diarrhea). Few other toxicity data are currently available.

Ritipenem 준비 용품 및 원자재

원자재

준비 용품


Ritipenem 공급 업체

글로벌( 7)공급 업체
공급자 전화 이메일 국가 제품 수 이점
Shaanxi Dideu Medichem Co. Ltd
+86-029-89586680 +86-18192503167
1026@dideu.com China 8331 58

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