아다멕신 C화학적 특성, 용도, 생산
Originator
Adamexine ,ZYF Pharm Chemical
Manufacturing Process
4.3 g 2-brommemtyl-4,6-dibromo-N,N-diacetylaniline and 1.65 g Nmethyladamantyl
amine in 100 ml of absolute ethanol were heated to reflux
for 8 hours. The ethanol was removed and a residue was washed with some
times with ether. The resulting hard mass was refluxed with 150 ml 2 N HCl
for 2 hours. The obtained product was cooled and stood for 10-12 hours at
4°C in a refrigerator. The crystalline 2-(N-(1-adamantyl)-Nmethylaminomethyl-
4',6'-dibromacetanilid hydrochloride (adamexine) was
filtered off and thoroughly washed with distilled water. It was recrystallized
from a mixture glacial acetic acid/water 2:1 (v/v) to give a white crystalline
powder, melting at 250°-254°C. The hydrochloride is better for a
pharmaceutical composition because of solubility in water. The free base may
be prepared by adding of an equivalent of any basic compound (NaOH,
NaHCO3 and so on).
Therapeutic Function
Mucolytic
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