(R)-(-)-이부프로펜
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(R)-(-)-이부프로펜 속성
- 녹는점
- 41-42°C
- 끓는 점
- 305.14°C (rough estimate)
- 밀도
- 1.0176 (rough estimate)
- 굴절률
- 1.5290 (estimate)
- 저장 조건
- Sealed in dry,2-8°C
- 용해도
- 클로로포름(약간 용해됨), 에탄올(약간 용해됨), 메탄올(약간 용해됨)
- 물리적 상태
- 백색 결정성 분말.
- 산도 계수 (pKa)
- 4.41±0.10(Predicted)
- 색상
- 무색~연한 베이지색 오일
- 수용성
- 369.3mg/L(25℃)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
안전지침서 | 24/25 | ||
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HS 번호 | 29155090 |
그림문자(GHS): | ||||||||||||||||||||||||||||||||||||
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신호 어: | Warning | |||||||||||||||||||||||||||||||||||
유해·위험 문구: |
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예방조치문구: |
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(R)-(-)-이부프로펜 C화학적 특성, 용도, 생산
개요
Ibuprofen is a non-steroidal anti-inflammatory drug with diverse biochemical actions, most notably inhibiting COX-1 and COX-2 (IC50s = 2.6 and 1.53 μM, respectively). It is commonly synthesized as a racemic mixture of (S) and (R) isomers (Item No. item 70280). (R)-Ibuprofen is an enantiomer that is generally not considered a COX inhibitor and is instead thought to be involved in pathways of lipid metabolism as it is incorporated into triglycerides along with fatty acids. The (R) enantiomer can, however, inhibit NF-κB activation (IC50 = 121.8 μM) in response to T-cell stimulation as well as block superoxide formation, β-glucuronidase release, and LTB4 generation by stimulated neutrophils (IC50 values range from 40-100 μM). 50-60% of (R)-ibuprofen is inverted to (S)-ibuprofen in humans after oral administration.화학적 성질
White Crystalline SolidPurification Methods
Crystallise the (+) and (-) acids from EtOH or aqueous EtOH. The racemate which crystallises from pet ether with m 75-77o is sparingly soluble in H2O and has IR (film) 1705 (C=O), 2300—3700 (OH broad)cm-1. It is used as a non-steroidal anti-inflammatory. [Shiori et al. J Org Chem 43 2936 1978, Kaiser et al. J Pharm Sci 65 269 1976, J Pharm Sci 81 221 1992, Freer Acta Cryst (C) 49 1378 1993 for the (S+)-enantiomer.](R)-(-)-이부프로펜 준비 용품 및 원자재
원자재
준비 용품
(R)-(-)-이부프로펜 공급 업체
글로벌( 150)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21666 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32836 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29888 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
Standardpharm Co. Ltd. | 86-714-3992388 |
overseasales1@yongstandards.com | United States | 14335 | 58 |
BOC Sciences | +1-631-485-4226 |
inquiry@bocsci.com | United States | 19553 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39916 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 |
sales@win-winchemical.com | China | 14350 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 |
1026@dideu.com | China | 23799 | 58 |
(R)-(-)-이부프로펜 관련 검색:
이소부틸아세토페논 이부프로펜
IBUPROFEN IMPURITY D,IBUPROFEN IMP D
IBUPROFEN IMPURITY J
1-Hydroxyibuprofen
(S)-(+)-Ibuprofen
2-[4-(2-Methylpropyl)phenyl] ethanol
6-isobutyl-3-methyl-2,3-dihydro-1H-inden-1-one
4-(2-Methylpropyl)benzeneethanol
Ibuprofen EP Impurity I
3-(4-ISOBUTYL-PHENYL)-PROPIONIC ACID
p-Isobutylstyrene
rac a-Hydroxy Ibuprofen
(2RS)-2-(4-N-PROPYLPHENYL)PROPANOIC ACID
trans-Ibuprofen IMpurity G
IBUPROFEN IMPURITY C,IBUPROFEN IMP C
IBUPROFEN IMP N
IBUPROFEN IMP F2,Ibuprofen methyl