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SR9238

SR9238 구조식 이미지

카스 번호:: 1416153-62-2

상품명:: SR9238

동의어(영문):: SR9238;SR9238 >=98% (HPLC);SR9238;SR-9238;SR 9238;Liver X receptor,SR-9238,SR 9238,LXR,SR9238,inhibit,Inhibitor;ethyl 5-{[N-({3'-methanesulfonyl-[1,1'-biphenyl]-4-yl}methyl)-2,4,6-trimethylbenzenesulfonamido]methyl}furan-2-carboxylate;Ethyl 5-((2,4,6-trimethyl-N-((3'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl)methyl)phenylsulfonamido)methyl)furan-2-carboxylate;Ethyl 5-(((2,4,6-trimethyl-N-((3'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl)methyl)phenyl)sulfonamido)methyl)furan-2-carboxylate;Ethyl 5-[[[[3'-(Methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl][(2,4,6-trimethylphenyl)sulfonyl]amino]methyl]-2-furancarboxylate;2-Furancarboxylic acid, 5-[[[[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl][(2,4,6-trimethylphenyl)sulfonyl]amino]methyl]-, ethyl ester

CBNumber:: CB43152748

분자식:: C31H33NO7S2

포뮬러 무게:: 595.73

MOL 파일:: 1416153-62-2.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 52

SR9238 속성

끓는 점: 787.7±70.0 °C(Predicted)

밀도: 1.268±0.06 g/cm3(Predicted)

저장 조건: 2-8°C

용해도: DMF: 5 mg/ml; DMF:PBS(pH7.2) (1:2): 0.3 mg/ml; DMSO: 5 mg/ml

산도 계수 (pKa): -10.53±0.70(Predicted)

물리적 상태: 가루

색상: 흰색에서 베이지색

안전

SR9238 C화학적 특성, 용도, 생산

용도

SR 9238 is an LXR inverse agonist, which also suppresses fibrosis in a model of non-alcoholic steatohepatitis.

Biochem/physiol Actions

SR9238 is liver selective LXR inverse agonist with high potency for both LXRα and LXRβ with an IC50 of 214 nM for LXRα and 43 nM for LXRβ. Metabolic syndrome is often accompanied by liver problems, such as fatty liver (nonalcoholic hepatosteatosis), associated with increased lipogenesis. Liver X receptors α and β (LXRα and LXRβ) are known to induce lipogenesis by increasing transcription of lipogenic enzyme genes, so it was hoped LXR antagonists might be of use in fatty liver. In a mouse model of nonalcoholic hepatosteatosis, SR9238 reduced the expression of lipogenic genes, and suppressed hepatic lipogenesis, inflammation and hepatic lipid accumulation. It was also effective in reduction of hepatic fibrosis in another study. Additionally in diet induced obese mice, SR9238 suppressed plasma cholesterol levels.

SR9238 준비 용품 및 원자재

원자재

준비 용품

SR9238 공급 업체

글로벌( 52)공급 업체

공급자	전화	이메일	국가	제품 수	이점
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Chemia Biotechnology（Shanghai） Co., Ltd	+8613816753574	info@chemia-pharm.com	CHINA	311	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57511	58
Nanjing Chemlin Chemical Co., Ltd	025-83697070 13913916777	info@chemlin.com.cn	China	19113	64
Sichuan Wei Keqi Biological Technology Co., Ltd.	028-81700200 18116577057	3003855609@qq.com	China	7887	56
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4334	55
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9806	58

SR9238 관련 검색:

2-AMINO-3-(4-CHLOROBENZOYL)-5,6,7,8-TETRAHYDROBENZOTHIOPHENE