EC330

EC330 구조식 이미지
카스 번호:
2016795-77-8
상품명:
EC330
동의어(영문):
EC330;EC-330; EC 330;EC-330,EC 330,EC330,inhibit,Inhibitor;Estra-4,9-dien-3-one, 11-(4-cyclopropylphenyl)-17-(1,1-difluoro-2-propyn-1-yl)-17-hydroxy-, (11β,17β)-;(8S,11R,13S,14S,17S)-11-(4-Cyclopropylphenyl)-17-(1,1-difluoroprop-2-yn-1-yl)-17-hydroxy-13-methyl-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
CBNumber:
CB43171691
분자식:
C30H32F2O2
포뮬러 무게:
462.57
MOL 파일:
2016795-77-8.mol

EC330 속성

끓는 점
623.4±55.0 °C(Predicted)
밀도
1.26±0.1 g/cm3(Predicted)
저장 조건
Store at -20°C
용해도
DMSO : 20 mg/mL (43.24 mM)
산도 계수 (pKa)
12.90±0.60(Predicted)

안전

HS 번호 2914409000

EC330 C화학적 특성, 용도, 생산

개요

EC330 is used as potential LIF inhibitors. The remaining EC330-like inhibitors include EC357, and EC363. They were designed based on the structure–activity relationship (SAR) studies on human breast cancer MCF7 cells with LIF overexpression. The SAR established through this screening includes following criteria: (i) the steroidal skeleton of the molecule is an antiprogestin, (ii) the molecule has the specific 17α-difluoro acetylenic moiety, and (iii) nonpolar substituents at position 11 are preferred over polar substituents. EC330, EC357, and EC363 have all these features. EC330 inhibits the LIF/LIF-R signaling and blocks the promoting effects of LIF on growth and migration of cancer cells.[1].

EC330 준비 용품 및 원자재

원자재

준비 용품


EC330 공급 업체

글로벌( 43)공급 업체
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Aladdin Scientific
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Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696,15000506266 15000506266
China 4121 55
ShangHai Biochempartner Co.,Ltd 17754423994 17754423994
2853530910@QQ.com China 8011 62

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