3-METHYLCHOLANTHRENE

3-METHYLCHOLANTHRENE 속성

3-METHYLCHOLANTHRENE C화학적 특성, 용도, 생산

개요

3-Methylcholanthrene (3-MC) is a member of the polycyclic aromatic hydrocarbon (PAH) family and is used as an experimental cancer research chemical. As other PAHs, 3-MC might be found in trace quantities in coal tar and heavy-end petroleum hydrocarbons.

화학적 성질

3-Methylcholanthrene is a solid that crystallizes from benzene and ether as pale yellow prisms. 3-methylcholanthrene is insoluble in water and soluble in alcohol. It is combustible, and can react with oxidizing materials.

용도

3-Methylcholanthrene has been used to assess its tumor initiation activity by Bhas 42 cell transformation assay. It has also been used to induce the activity of cytochrome P450.

정의

ChEBI: A pentacyclic ortho- and peri-fused polycyclic arene consisting of a dihydrocyclopenta[ij]tetraphene ring system with a methyl substituent at the 3-position.

일반 설명

Yellow crystals or solid.

공기와 물의 반응

Insoluble in water.

반응 프로필

3-METHYLCHOLANTHRENE can react with oxidizing materials. Ozone and chlorinating agents oxidize 3-METHYLCHOLANTHRENE.

위험도

Powerful carcinogen.

화재위험

Flash point data for 3-METHYLCHOLANTHRENE are not available; however, 3-METHYLCHOLANTHRENE is probably combustible.

Safety Profile

Suspected carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Poison by intravenous and intraperitoneal routes. Experimental teratogenic and reproductive effects. Human mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.

잠재적 노출

The coke-oven plant is the principal source of coal tar. The hot gases and vapors produced during the conversion of coal to coke are collected by means of a scrubber, which condenses the effluent into ammonia, water, crude tar, and other by-products. Crude tar is separated from the remainder of the condensate for refining and may undergo further processing. Employees may be exposed to pitch and creosote in metal and foundry operations; when installing electrical equipment; in construction, railway, utility; and briquette manufacturing.

Carcinogenicity

3-Methylcholanthrene is a rapid, all-around neoplastic agent and a potent liver tumorigen.

환경귀착

3-MC, when released to soil, adsorbs strongly to the soil and does not leach. It does not biodegrade or hydrolyze significantly but may evaporate from dry soil. If released to water, it is expected to adsorb strongly to sediment and to bioconcentrate in aquatic organisms. If released into the atmosphere, it may be subject to direct photolysis because it absorbs strongly in the ultraviolet (UV) spectrum of light. It may also react with peroxyl radicals already present in the atmosphere. Its estimated half-life in the atmosphere is 2.8 h. Considering an octanol/ water log concentration ratio of 6.42, a bioconcentration factor of 45 000 has been estimated.

운송 방법

UN1136 Coal tar distillates, flammable, Hazard Class: 3; Labels: 3-Flammable liquid

비 호환성

Incompatible with strong oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Phenols, such as creosote react as weak organic acids. Phenols and cresols are much weaker as acids than common carboxylic acids (phenol has pKa = 9.88). These materials are incompatible with strong reducing agents such as hydrides, nitrides, alkali metals, and sulfides. Flammable hydrogen gas is often generated, and the heat of the reaction may ignite the gas. Heat is also generated by the acid-base reaction between phenols and bases. Such heating may initiate polymerization of the organic compound. Phenols are sulfonated very readily (e.g., by concentrated sulfuric acid at room temperature). The reactions generate heat. Phenols are also nitrated very rapidly, even by dilute nitric acid

폐기물 처리

Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed.

3-METHYLCHOLANTHRENE 준비 용품 및 원자재

원자재

준비 용품

3-METHYLCHOLANTHRENE 공급 업체

공급자	전화	이메일	국가	제품 수	이점
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418671	sales@tnjchem.com	China	34572	58
Finetech Industry Limited	+86-27-87465837 +8618971612321	info@finetechnology-ind.com	China	9702	58
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	info@dycnchem.com	CHINA	52867	58
Shaanxi Didu New Materials Co. Ltd	+86-89586680 +86-13289823923	1026@dideu.com	China	9116	58
GIHI CHEMICALS CO.,LIMITED	+8618058761490	info@gihichemicals.com	China	49999	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8474	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+undefined18621343501	product@acmec-e.com	China	33349	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58

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