The cultivation of human and murine IL-2 dependent T-cell lines and natural killer cell lines.
The proliferation of mitogen-activated T-lymphocytes and natural killer cells.
The establishment of human and murine thymocyte, splenocyte, or peripheral blood lymphocyte (PBL) derived T-cell lines.
The generation of human and murine lymphokine-activated killer (LAK) cells (1-11).
In vitro re-stimulation of lung cells obtained from mice.
일반 설명
Recombinant Interleukin-2, human (hIL-2) is produced in E. coli and purified by standard chromatographic techniques. Solution in PBS and 1 mg/ml BSA, filtered through a 0.2 μm pore size membrane.
Biochem/physiol Actions
Interlekin-2 (IL-2) is a potent pro-inflammatory cytokine. It plays a protective role in autoimmune chronic inflammation, when present in low amounts. It is involved in maintaining immune homeostasis where it controls the cross-talk between T regulatory and T effector cells. Studies in acute myelogenous leukemia (AML) mice models show that antibody based delivery of IL-2 to targets present in tumor-linked vasculature results in antileukemic activity.
