6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile
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6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile 속성
- 밀도
- 1.88±0.1 g/cm3(Predicted)
- 산도 계수 (pKa)
- 6.41±0.30(Predicted)
- InChI
- InChI=1S/C8H4BrN3O/c9-6-1-7(13)8-5(2-10)3-11-12(8)4-6/h1,3-4,13H
- InChIKey
- IFUVDUFAFVWZOT-UHFFFAOYSA-N
- SMILES
- C12=C(C#N)C=NN1C=C(Br)C=C2O
안전
6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile C화학적 특성, 용도, 생산
용도
6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile is a pharmaceutical intermediate used in the preparation of Selpercatinib, an FDA-approved drug for the treatment of RET-positive advanced non-small cell lung cancer (NSCLC), thyroid cancer and certain other cancersSynthesis
At room temperature, add 6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile (50g, 198.36mmol) and water (16.5mL, 916mmol) in a 1L single-neck flask in sequence, Sodium hydroxide (16.03g, 396.8mmol), DMA (500mL), stirred at room temperature for 5min, then transferred to 0°C, slowly added dodecanethiol (97mL, 397mmol), after the addition, the reaction was moved to 45°C overnight. Pour the reaction solution into 3L ice water, slowly add saturated citric acid water to adjust the PH=5, stir for half an hour, and then stand still filter, wash the filter cake with water and petroleum ether several times, and dry at 60°C to obtain 44.1g of yellow solid 6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile (6-Bromo-4-hydroxypyrazolo[1,5-a]pyridine-3-carbonitrile).6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile 준비 용품 및 원자재
원자재
준비 용품
6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile 공급 업체
글로벌( 42)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Xiamen Yunfan Biotech Co.,Ltd. | +8618050056030 |
yezhaobao@yfpharm.com | China | 20 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 18223 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32686 | 60 |
| Shochem(Shanghai) Co.,Ltd | 86-21-50800795 |
info@shochem.com | CHINA | 288 | 58 |
| ENBRIDGE PHARMTECH CO., LTD. | +8613812269233 |
tinayang@enbridgepharm.com | China | 303 | 58 |
| Suzhou Ryan Pharmachem Technology Co.,Ltd. | +86-512-68780025 +8618962125825 |
sales@ryanchem.com | China | 137 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 |
contact@labnetwork.com | China | 19994 | 58 |
| Golden Pharma Co., Limited | +undefined18958062155 |
sales@zjgoldpharm.com | China | 5905 | 58 |
| Meike meditech (Foshan) Co.,Ltd | +86-0757-22239986 +86-18029359586 |
sales@mkmeditech.com | China | 1134 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 |
Mandy@hangyubiotech.com | China | 11013 | 58 |