눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P308+P313
노출 또는 접촉이 우려되면 의학적인 조치· 조언를 구하시오.
P321
(…) 처치를 하시오.
P330
입을 씻어내시오.
P332+P313
피부 자극이 생기면 의학적인 조치· 조언을 구하시오.
P337+P313
눈에 대한 자극이 지속되면 의학적인 조치· 조언를 구하시오.
P405
밀봉하여 저장하시오.
P501
...에 내용물 / 용기를 폐기 하시오.
CINACALCET C화학적 특성, 용도, 생산
개요
Cinacalcet is the first type II calcimimet ic agent approved that improves CaSR sensi Tivity to calcium .
When calcium is bound to the CaSR, phospholipase C is act ivated, and the secretion of PTH is inhibited. In the
presence of cinacalcet , not only is a drop in
PTH levels observed but also a decrease in serum calcium and phosphorous levels.
화학적 성질
Yellow Oil
용도
Cinacalcet is the first calcimimetic drug approved by the United States Food and Drug Administration for the treatment of secondary hyperparathyroidism in patients with chronic kidney disease
정의
ChEBI: Cinacalcet is a secondary amino compound that is (1R)-1-(naphthalen-1-yl)ethanamine in which one of the hydrogens attached to the nitrogen is substituted by a 3-[3-(trifluoromethyl)phenyl]propyl group. It has a role as a calcimimetic and a P450 inhibitor. It is a member of naphthalenes, a secondary amino compound and a member of (trifluoromethyl)benzenes.
Clinical Use
Cinacalcet hydrochloride is a second-generat ion calcimimetic approved for the treatment of secondary
hyperparathyroidism in patients wi th chronic kidney disease on dialysis and for the treatment of hypercalcemia
in patients with parathyroid cancer . It can be used alone, with vitamin D, and/or with a phosphate binder .
