AR-R 17779 hydrochloride
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AR-R 17779 hydrochloride 속성
- 저장 조건
- -20°C
- 용해도
- <10.93mg/ml in DMSO; <21.87mg/ml in H2O
- 물리적 상태
- 가루
- 색상
- 흰색에서 베이지색
- optical activity
- [α]/D -59 to -69°, c = 1.0 in methanol
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
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| 신호 어: | Danger | ||||||||||||||||||||||||||||
| 유해·위험 문구: |
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| 예방조치문구: |
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AR-R 17779 hydrochloride C화학적 특성, 용도, 생산
용도
AR-R 17779 Hydrochloride is a selective α7 nicotinic receptor agonist.Biochem/physiol Actions
AR-R17779 is a nicotinic acetylcholine receptor alpha7 full agonist that targets α7 nAChR with high affinity (Ki = 92 nM/rat α7 against 5 nM α-BTX vs.16 μM/rat α4β2 against 3 nM (-)-nicotine) and selectivity (EC50 = 6.2/10/12.7 μM using human/rat/monkey α7 nAChR-Xenopus oocyte by whole cell voltage clamp, no antagonistic activity against acetylcholine using human α4β2-, α3β4-, α3β2-, α3β2α5-expressing oocytes or antagonistic activity against 5-HT using rat 5HT3a-exxpressing oocytes). AR-R17779 exhibits cognition-improving efficacy in rats (1-20 mg/kg s.c) and mice (1-20 mg/kg i.p.) in vivo and is widely employed for studying other α7 nAChR-dependent physiological functions.AR-R 17779 hydrochloride 준비 용품 및 원자재
원자재
준비 용품
AR-R 17779 hydrochloride 공급 업체
글로벌( 12)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Sigma-Aldrich | 021-61415566 800-8193336 |
orderCN@merckgroup.com | China | 51471 | 80 |
| EMMX Biotechnology LLC | 888-539-0666 |
info@emmx.com | United States | 8449 | 60 |
| Lancrix Chemicals | 86-21-50817262 |
sales@lancrix.com | China | 1503 | 55 |
| BOC Sciences | -- |
info@bocsci.com | USA | 0 | 65 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 |
order@med-bio.cn | China | 8141 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 |
marketing@energy-chemical.com | China | 44941 | 58 |
| Changzhou Furuisi Biotechnology Co., Ltd | 0519-85524369 |
3477467573@qq.com | China | 8618 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223; |
psaitong@jm-bio.com | China | 29778 | 58 |
| Carbosynth | -- |
sales@carbosynth.com | United Kingdom | 6018 | 58 |
| ApexBio Technology | -- |
sales@apexbt.com | United States | 6254 | 58 |