COT Human DNA is used in the following applications:
Nucleic acid labeling and detection
DNA Microarray applications such as comparative genome hybridization and sequence capture
Complex hybridization of human nucleic acids like FISH
In microarray applications, COT Human DNA is used in hybridization solutions to block repetitive DNA sample sequences from nonspecific hybridizations. In filter and other hybridization techniques, COT Human DNA is also used in pre-hybridization solutions to inactivate nonspecific target binding sites. In all applications customers would like to suppress nonspecific signals most efficiently. The scientific field targeted with this product is for scientists interested in the analysis of genomic variations within the human genome.
일반 설명
COT Human DNA is prepared from human placental DNA by shearing, denaturing, and reannealing under conditions that enrich highly repetitive elements. It can be used to suppress cross-hybridization to human repetitive DNA when human DNA probes are hybridized in situ. General applications are FISH and DNA microarray hybridizations such as comparative genome hybridization as well as all applications where complex human DNA is used as a target or probe during hybridization experiments.
