HHATL Polyclonal Antibody

HHATL Polyclonal Antibody C화학적 특성, 용도, 생산

개요

Hedgehog acyltransferase-like (HHATL) is the mammalian homolog of yeast Gup1 that is encoded by the HHATL gene in humans. HHATL is a membrane-bound O-acyltransferase (MBOAT) superfamily member and contains multiple transmembrane domains common to this family but lacks acyltransferase function due to a single amino acid substitution of histidine for leucine at position 447. It is localized to the endoplasmic reticulum (ER) and is expressed in the heart, skeletal muscle, and brain. HHATL colocalizes with sonic hedgehog (Shh) and is a negative regulator of Shh N-terminal palmitoylation, a post-translational modification that is critical for Shh signaling in neural development and embryogenesis. Hhatl^-/- neonatal mice fail to develop proper suckling ability, leading to malnutrition and death by postnatal day 14. HHATL expression is decreased in six nasopharyngeal carcinoma cell lines, as well as in tissue isolated from patients with nasopharyngeal carcinoma or skin squamous cell carcinoma. Cayman''s HHATL Polyclonal Antibody can be used for flow cytometry (FC), immunofluorescence (IF), and Western blot applications. The antibody recognizes HHATL at ~60 kDa from human samples.

HHATL Polyclonal Antibody 준비 용품 및 원자재

원자재

준비 용품

HHATL Polyclonal Antibody 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Shanghai Haoran Biotechnology Co., Ltd.	--	470003480@QQ.COM	CHINA	6968	58
Boao Pike	--	lyn@biopike.com.cn	CHINA	6629	58
Shanghai Minmin Biotechnology Co., Ltd.	--	1914109725@qq.com	CHINA	6530	58
Thermo Fisher Scientific	--	sales.china@thermofisher.com	CHINA	5672	58
Morning Student Science and Technology (Guangzhou) Co., Ltd.	--	chenxue_gz@163.com	CHINA	6618	58
Shanghai Benrui Biotechnology Co., Ltd.	--	john.st@163.com	CHINA	1472	58
Arnold Biotech Co., Ltd. (Abnova)	--	sales@abnova.com	CHINA	4484	58
Cayman Chemical Company	--	cayman@caymanchem.com	United States	6618	81