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2-AMINO-5-(4-CHLOROBENZYLTHIO)1,3,4-THIADIAZOLE

2-AMINO-5-(4-CHLOROBENZYLTHIO)1,3,4-THIADIAZOLE 구조식 이미지

카스 번호:: 72836-33-0

상품명:: 2-AMINO-5-(4-CHLOROBENZYLTHIO)1,3,4-THIADIAZOLE

동의어(영문):: TIMTEC-BB SBB005594;2-AMINO-5-(4-CHLOROBENZYLTHIO)1,3,4-THIADIAZOLE;5-((4-CHLOROBENZYL)THIO)-1,3,4-THIADIAZOL-2-AMINE;5-[(4-CHLOROBENZYL)SULFANYL]-1,3,4-THIADIAZOL-2-AMINE;[5-[(4-chlorobenzyl)thio]-1,3,4-thiadiazol-2-yl]amine;5-[(4-CHLOROBENZYL)SULFANYL]-1,3,4-THIADIAZOL-2-YLAMINE;5-[(4-chlorophenyl)methylthio]-1,3,4-thiadiazol-2-amine;1,3,4-Thiadiazol-2-amine, 5-[[(4-chlorophenyl)methyl]thio]-;5-[(4-chlorophenyl)methylsulfanyl]-1,3,4-thiadiazol-2-amine

CBNumber:: CB7208144

분자식:: C9H8ClN3S2

포뮬러 무게:: 257.76

MOL 파일:: Mol file

속성

안전

용도

공급 업체 12

2-AMINO-5-(4-CHLOROBENZYLTHIO)1,3,4-THIADIAZOLE 속성

녹는점: 168-169 °C(Solv: ethyl acetate (141-78-6))

끓는 점: 443.8±47.0 °C(Predicted)

밀도: 1.50±0.1 g/cm3(Predicted)

산도 계수 (pKa): 2.41±0.10(Predicted)

안전

위험품 표기	Xi
위험 참고 사항	Irritant
HS 번호	2934999090

2-AMINO-5-(4-CHLOROBENZYLTHIO)1,3,4-THIADIAZOLE C화학적 특성, 용도, 생산

일반 설명

An orally bioavailable, non-toxic, thio-thiadiazolamine compound that specifically inhibits the DNA-binding capacity of virulence regulator, RegA (IC₅₀ = 1.7 μM in E. coli strain MC4100 (kfc-lacZ, pACYC184-regA), by interacting with amino acid residues within a conserved region of the DNA-binding domain, but without affecting RegA dimerization. Interacts with the double helix-turn-helix (HTH) domain that results in a loss of binding affinity of RegA for its DNA targets. This interaction appears to involve W188 and R223 residues that are conserved in several RegA homologs including ToxT, AggR, RegR, and Rns. Shown to be highly effective in reducing Citrobacter rodentium colonization when administered perorally to mice (~50 mg/kg) either 15 minutes before or 12 hours after bacterial inoculation. Reduces the ability of Rns and RegR to activate the transcription of their target promoters, but does not affect the activity of AggR and ToxT.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Biochem/physiol Actions

Cell permeable: yes

2-AMINO-5-(4-CHLOROBENZYLTHIO)1,3,4-THIADIAZOLE 준비 용품 및 원자재

원자재

준비 용품

2-AMINO-5-(4-CHLOROBENZYLTHIO)1,3,4-THIADIAZOLE 공급 업체

글로벌( 12)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Changzhou Hopschain Chemical Co.,Ltd.	0519-85528066 13775048983	sales@hopschem.com	China	31557	55
Nanjing Shizhou Biology Technology Co.,Ltd	--	purchase@synzest.com	China	6857	58

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