스페르미딘 트리하이드로클로라이드

스페르미딘 트리하이드로클로라이드 속성

스페르미딘 트리하이드로클로라이드 C화학적 특성, 용도, 생산

개요

Spermidine trihydrochloride is a polyamine that inhibits neuronal nitric oxide synthase (nNOS) and binds and precipitates DNA. It may be used to purify DNA binding proteins. Additionally, spermidine stimulates T4 polynucleotide kinase activity. It is involved in growth, development, and the stress response in plants.

화학적 성질

Spermidine trihydrochloride appears as white to off-white crystalline powder, which is soluble in water(100mg/ml-clear, colorless solution), very hygroscopic, and air-sensitive.

화학 반응

Spermidine hydrochloride is a white crystal at normal temperature and pressure. It is the hydrochloride form of spermidine.When it is used, it is often reacted with alkali to release a triamine structure.

용도

Spermidine Trihydrochloride is a NOS1 inhibitor and NMDA and T4 activator. Polyamine that plays an important role in the regulation of cellular proliferation and differentiation. It was in a structural and functional study of polyamines, where potassium and sodium ions were found to promote different effects when binding with polyamines. Spermidine trihydrochloride has been used in fourier transform infrared spectroscopy (FTIR)characterization and in zeta-potential measurements.

benefits

Spermidine trihydrochloride has been extensively studied for its potential health benefits, including its ability to modulate autophagy, enhance cardiovascular health, protect against neurodegenerative diseases, and exhibit antioxidant activity. Studies have shown that it can enhance cardiovascular health by promoting blood vessel relaxation, reducing oxidative stress, and improving mitochondrial function. It has also been suggested to have neuroprotective effects and may contribute to cognitive health and brain function. It has shown promising results in preclinical studies, demonstrating its ability to protect neurons, reduce inflammation, and enhance cellular resilience.

Biological Functions

Spermidine inhibits NOS1 (nNOS). Spermidine binds and precipitates DNA and may be used for purification of DNA binding proteins. Spermidine activates PNK (polynucleotide kinase T4). Spermidine binds to and activates NMDA and has been shown to potentiate NMDA-induced currents in a concentration-dependent manner.

일반 설명

Spermidine trihydrochloride is the hydrochloric acid neutralized salt of spermidine. Spermidine is a polyamine and a trivalent organic cation. It is a natural polyamine that stimulates cytoprotective macroautophagy/autophagy. External supplementation of spermidine extends lifespan and health span across species, including in yeast, nematodes, flies and mice. Spermidine trihydrochloride is a more stable form because spermidine is very air sensitive.

생물학적 활성

Binds to the polyamine modulatory site of the NMDA receptor and has been described as an agonist based on its ability to enhance the binding of [ 3 H]-MK801.
Spermidine trihydrochloride is an aliphatic polyamine. Its crystalline structure has been studied. It has been reported to preserve the nuclei and prevent proteolytic degradation of histones during the macronuclei isolation from Tetrahymena pyriformis.

Purification Methods

Recrystallise the salt from dry 3% HCl in ethanol and adding dry Et2O if necessary. Filter it off rapidly and dry it in a vacuum desiccator. Alternatively centrifuge the crystals off, wash them with dry Et2O and dry them in a vacuum. [Beilstein 4 IV 1300.]

스페르미딘 트리하이드로클로라이드 준비 용품 및 원자재

원자재

준비 용품

스페르미딘 트리하이드로클로라이드 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Wuhan Konberd Biotech Co., Ltd	+undefined18986093962	admin@konberdbio.com	China	1376	58
Wuhan senwayer century chemical Co.,Ltd	+undefined-27-86652399 +undefined13627115097	market02@senwayer.com	China	875	58
Bonerge(Hunan) Lifescience Co., Ltd.	+86-731-82791134 +86-18801900056	hank.h@bonerge.com	China	30	58
Maintain Biotech Co., Ltd.	+86-75589664337 +86-15112661142	cami@maintain-bio.com	China	66	58
Suzhou Yuanrui Bio-Tech Co., Ltd	+86-18106132862 +86-18106132862	sales02@yuanruibio.com	China	278	58
GIHI CHEMICALS CO.,LIMITED	+8618058761490	info@gihichemicals.com	China	50000	58
Wuhan Haorong Biotechnology Co.,ltd	+8618565342920	sales@chembj.net	China	270	58
Hangzhou Zelixir Biotech Co., Ltd.	+8618867646786	neal.chen@zelixir.com	China	229	58
airuikechemical co., ltd.	+undefined86-15315557071	sales02@airuikechemical.com	China	994	58
Shanghai Bojing Chemical Co.,Ltd.	+86-86-02137122233 +8613795318958	bj1@bj-chem.com	China	298	55

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