TRYPSINOGEN

TRYPSINOGEN 속성

TRYPSINOGEN C화학적 특성, 용도, 생산

용도

Trypsinogen from bovine pancreas is suitable for use in:

• the secondary structure analysis of proteins in H2O solution using single-pass attenuated total reflection Fourier transform infrared (ATR-FT-IR) microscopy
• tuning and calibration of electrospray ionization quadrupole time-of-flight (ESI-Q-TOF) mass spectrometer
• the secondary structure analysis of proteins by infrared (IR) spectroscopy
• SDS-PAGE as a molecular weight standard (24kDa)

일반 설명

Trypsinogen is a proenzyme (zymogen) that is activated to form trypsin. It is synthesized in the pancreas and activated by enterokinase once it reaches the lumen of the small intestine. Bovine trypsinogen is a single polypeptide chain of 229 amino acids that is cross linked by six disulfide bridges. Enterokinase cleaves a hexapeptide to from the NH₂ terminus of trypsinogen at the Lys6 - Ile7 peptide bond and activates it. Trypsin, thus formed, autocatalytically activates more trypsinogen to trypsin. This native form of trypsin is called β-trypsin, which undergoes autolysis at Lys₁₃₁ - Ser₁₃₂ resulting in α-trypsin that is held together by disulfide bridges. Trypsin is a serine protease with His₄₆ and Ser₁₈₃ at the active site. The pH optimum of trypsin is 7 - 9.

Biochem/physiol Actions

Hereditary pancreatitis was shown to be caused by a Arg-His substitution at residue 117 of trypsinogen causing auto-activation of trypsinogen to trypsin.

TRYPSINOGEN 준비 용품 및 원자재

원자재

준비 용품

TRYPSINOGEN 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Nanjing Sunlida Biological Technology Co., Ltd.	025-57798810	sales@sunlidabio.com	China	3750	55
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80
Raw material medicin reagent co.,Ltd	025-57798860	sales@njromanme.com	China	4534	58
Beijing OKA biological technology co., LTD	010-62971590 18548936886	3462612863@qq.com	China	6912	58
Shanghai Sig Biotechnology Co., LTD	021-57810052 18930344717	2089316240@qq.com	China	9396	58
Wuhan Yanzhe Technology Co., Ltd	15527250409	wenhaotian12@163.com	China	4576	58
Shaanxi DIDU pharmaceutical and Chemical Co., Ltd	17691182729 18161915376	1046@dideu.com	China	10008	58
Beijing Baileisen Biotechnology Co., Ltd.	13581502185	joe0415zhaxi@163.com	China	139	58

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