yk11

yk11 속성

yk11 C화학적 특성, 용도, 생산

개요

YK11 was first studied by Japanese researcher Yuichiro Kanno in 2011. It was found to be a partial agonist of the androgen receptor (AR), genetically selective, leading researchers to believe the compound was a SARM. YK11 is an experimental drug candidate and an unapproved substance for use in humans.

용도

YK-11 is a synthetic steroidal selective androgen receptor modulator (SARM).It is a gene-selective partial agonist of the androgen receptor (AR) and does not induce the physical interaction between the NTD/AF1 and LBD/AF2 (known as the N/C interaction), which is required for full transactivation of the AR.

benefits

Better Bones: YK11 works by binding to androgen receptors in the body, which are found in various tissues, including bones. Once attached, it activates genes that promote bone growth and mineralization. It means that YK11 could help individuals with osteoporosis or those looking to improve their bone density. Yk11 may increase bone density and mineralization, leading to stronger and healthier bones. It elevates mobility and reduces the risk of fractures.Inhibits Protein Myostatin: Yk11 plays a role in reducing the levels of a protein called myostatin, which is responsible for limiting muscle growth in the body. Yk11 stimulates the production of follistatin, which inhibits myostatin production. Myostatin acts as a regulator, preventing muscles from growing beyond a certain point.

Mechanism of action

YK-11 is an androgen receptor partial agonist that activates androgen receptor transcriptional activity in HEK293 cells overexpressing androgen receptors when used at a concentration of 0.1 μM.1 It induces expression of the androgen receptor target genes FKBP51 and FGF18 in HEK293 cells when used at a concentration of 10 μM. YK-11 accelerates nuclear translocation of androgen receptors without inducing interaction between the androgen receptor N- and C-termini. In C2C12 cells, YK-11 (500 nM) increases expression of the myogenic regulatory factors MyoD, Myf5, and myogenin, as well as follistatin (Fst), and induces myogenic differentiation.

참고 문헌

[1] Yuichiro Kanno, et al. Exp Cell Res. Differential DNA-binding and cofactor recruitment are possible determinants of the synthetic steroid YK11-dependent gene expression by androgen receptor in breast cancer MDA-MB 453 cells DOI:10.1016/j.yexcr.2022.113333
[2] Su Jin Lee, et al. Biochem Biophys Res Commun. Myostatin inhibitor YK11 as a preventative health supplement for bacterial sepsis DOI:10.1016/j.bbrc.2021.01.030
[3] Tomofumi Yatsu, et al. Biol Pharm Bull. Selective Androgen Receptor Modulator, YK11, Up-Regulates Osteoblastic Proliferation and Differentiation in MC3T3-E1 Cells DOI:10.1248/bpb.b17-00748
[4] Mario Thevis, et al. Mol Cell Endocrinol. Detection of SARMs in doping control analysis DOI:10.1016/j.mce.2017.01.040
[5] Yuichiro Kanno, et al. Biol Pharm Bull. Selective androgen receptor modulator, YK11, regulates myogenic differentiation of C2C12 myoblasts by follistatin expression DOI:10.1248/BPB.B13-00231

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yk11 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10522	58
Wuhan Cell Pharmaceutical Co., Ltd	+86-13129979210 +86-13129979210	sales@cellwh.com	China	376	58
Zhuzhou New Peptides Tech Co.,Ltd.	+86-18073326374 +86-18073326374	sales@goodpeptides.com	China	145	58
qingdao future trading Co., Ltd	+86-13335044410 +86-13335044410	cui56813@163.com	China	110	58
Wuhan Ruichi Technology Co., Ltd	+8613545065237	admin@whrchem.com	China	161	58
Shaanxi Xianhe Biotech Co., Ltd	+8617709210191	Jerry@xhobio.com	China	484	58
Hebei Mojin Biotechnology Co., Ltd	+86 13288715578 +8613288715578	sales@hbmojin.com	China	12446	58
Dorne Chemical Technology co. LTD	+86-86-13583358881 +8618560316533	Ethan@dornechem.com	China	3137	58
Firsky International Trade (Wuhan) Co., Ltd	+8615387054039	admin@firsky-cn.com	China	436	58
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971 +86-17331933971	deasea125996@gmail.com	China	2503	58

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