ANTI-SKI

ANTI-SKI C화학적 특성, 용도, 생산

용도

The reagent is designed for Flow Cytometry analysis. Suggested working dilution is 1:50. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.

일반 설명

The antibody SIT-01 reacts with SHP2-interacting transmembrane adaptor protein (SIT) expressed exclusively in lymphoid organs. It weakly crossreacts with mouse SIT.

Biochem/physiol Actions

SIT1 (Signaling threshold-regulating transmembrane adapter-1) inhibits T-cell receptor signaling and T-cell receptor-mediated phosphorylation of AKT (RAC-γ serine/threonine-protein kinase). Down-regulation of SIT1 promotes T-cell receptor-mediated AKT (RAC-α serine/threonine-protein kinase) activation and causes inactivation of FOXO1 (Forkhead box protein O1), a transcription factor that inhibits cell cycle progression and regulates T-cell homeostasis. SIT1 is involved in positive selection of T-cells. It regulates the signals required for thymic selection and peripheral T-cell activation.

ANTI-SKI 준비 용품 및 원자재

원자재

준비 용품

ANTI-SKI 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Shanghai Beinuo Biotechnology Co., Ltd.	--	beinuobio@163.com	CHINA	6580	58
Guangzhou Dongrui Technology Co., Ltd.	--	xiaoshan.wu@dr-tech.com.cn	CHINA	2839	58
Beijing Qiangxin Borui Biotechnology Co., Ltd.	--	moumou@xxx.com	CHINA	2992	58
Riedel-de Haen AG	--		United States	6825	87
Fluorochem Ltd	--	vernam@fluorochem.co.uk	United Kingdom	6383	65
Fluorochem Ltd.	--	enquiries@fluorochem.co.uk	United Kingdom	6406	74
Alexis Corporation	--	alexis-ch@alexis-corp.ch	Switzerland	3599	74
Kamiya Biomedical Company	--	ordering@kamiyabiomedical.com	United States	736	72
A.G. Scientific, Inc.	--	support@agscientific.com	United States	1066	71