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Bufalin

Bufalin 구조식 이미지
카스 번호:
465-21-4
상품명:
Bufalin
동의어(영문):
BUFALIN;Bufalin std.;Bufalin, >=98%;BUFALIN90%,99%;Bufalin, 98%, from bufonis venenum;3,14-dihydroxybufa-20,22-dienolide;5β,20(22)-Bufadienolide-3β,14-diol;Bufalin - CAS 465-21-4 - Calbiochem;3β,14-Dihydroxy-5β,20(22)-bufadienolide;5BETA,20[22]-BUFADIENOLIDE-3BETA,14-DIOL
CBNumber:
CB8219888
분자식:
C24H34O4
포뮬러 무게:
386.52
MOL 파일:
465-21-4.mol

Bufalin 속성

녹는점
242-243°
알파
D -20°
저장 조건
2-8°C
물리적 상태
White to off-white solid
InChIKey
QEEBRPGZBVVINN-ONGIWDLKSA-N
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 T+
위험 카페고리 넘버 28
안전지침서 28-36/37-45
유엔번호(UN No.) UN 3462 6.1/PG 2
WGK 독일 3
RTECS 번호 EI2962500
위험 등급 6.1(a)
포장분류 II
HS 번호 29322090
그림문자(GHS):
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H300 삼키면 치명적임 급성 독성 물질 - 경구 구분 1,2 위험 P264, P270, P301+P310, P321, P330,P405, P501
예방조치문구:
P264 취급 후에는 손을 철저히 씻으시오.
P264 취급 후에는 손을 철저히 씻으시오.
P301+P310 삼켰다면 즉시 의료기관(의사)의 진찰을 받으시오.

Bufalin MSDS


3-b,14-Dihydroxy-5-beta-bufa-20,22-dienolide

Bufalin C화학적 특성, 용도, 생산

용도

A bufadienolide derivative, cardiac steroid, a component of bufadienolides present in the traditional Chinese medicine Chan'su, used therapeutically for the treatment of heart disease, also has been reported as a protective factor in many tumors.

정의

ChEBI: A 14beta-hydroxy steroid that is bufan-20,22-dienolide having hydroxy substituents at the 5beta- and 14beta-positions. It has been isolated from the skin of the toad Bufo bufo.

위험도

Toxic.

효소 저해제

This cardioactive C-24 steroid (FW = 386.52 g/mol; CAS 465-21-4; Solubility: 5 mg/mL chloroform, 25 mg/mL DMSO), also named 3,14- dihydroxybufa-20,22-dienolide;5β,20(22)-bufadienolide-3β,14-diol and 3β,14-dihydroxy-5β,20(22)-bufadienolide, is the major digoxin-like immunoreactive component of Chansu, a traditional Chinese medicine prepared from the skin and venom-containing parotid gland of a poisonous toad. Bufalin increases the doubling time of three prostate cancer cell lines, inducing apoptosis and the caspase-3 activity. Expression of other proapoptoptic factors, such as mitochondrial Bax and cytosolic cytochrome c, were also increased. Bufalin also reduces serum-induced invasiveness of human hepatocellular cancer SK-Hep1 cells, markedly inhibiting MMP-2 and MMP-9 activities. It also attenuates phosphoinisitide-3-kinase (PI3K) and AKT phosphorylation was associated with reduced levels of NF- κB. Bufalin also suppresses protein levels of FAK, Rho A, VEGF, MEKK3, MKK7, and uPA. Such observations indicate that bufalin is as an antiinvasive agent that inhibits MMP-2 and -9 and alters PI3K/AKT and NF- κB signaling pathways.

Bufalin 준비 용품 및 원자재

원자재

준비 용품


Bufalin 공급 업체

글로벌( 129)공급 업체
공급자 전화 팩스 이메일 국가 제품 수 이점
Chengdu Biopurify Phytochemicals Ltd.
18080483897
maggie@biopurify.com CHINA 2236 58
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
Kono Chem Co., Ltd
+86-132 8924 6953(Whatsapp/Wechat)
+86-29-86107037 info@konochemical.com CHINA 2540 58
Hubei Jusheng Technology Co.,Ltd.
86-188-71490254
peter@hubeijusheng.com CHINA 20084 58
Shaanxi Pioneer Biotech Co., Ltd .
86-13259417953(Whatsapp)
029-84385017 sales@pioneerbiotech.com CHINA 1510 58
Baoji Herbest Bio-Tech Co.,Ltd. +86-917-8888998
+86-917-3313696 herbest3@gmail.com China 375 58
Shanghai BeiZhuo Biotech Co., Ltd. 021-61119791/13386096464
021-50190009 bzswkf@foxmail.com China 3932 50
Chengdu Biopurify Phytochemicals Ltd. 86-28-82633397
+86-28-82633165 sales@biopurify.com China 1993 60
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
Chembest Research Laboratories Limited +86(0)21-20908456
+86(0)21-58180499 sales@biochembest.com; market@biochembest.com China 5997 61

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