AMINEPTINE HCL
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AMINEPTINE HCL 속성
- 녹는점
- 226-230°
안전
AMINEPTINE HCL C화학적 특성, 용도, 생산
Originator
Survector,Eutherapie,France,1978Manufacturing Process
6.5 g of 5-chloro-10,11-dihydro-5H-dibenzo[a,d]cycloheptene in 60 ml of nitromethane and 10.8 g of ethyl 7-aminoheptanoate in 12ml of nitromethane were mixed at ambient temperature. The reaction was slightly exothermic. The reaction mixture was left to stand overnight and the solvent was evaporated in vacuum. The residue was taken up in normal hydrochloric acid and the resulting precipitate was filtered off.10.5 g of crude ethyl 7-[dibenzo(a,d)cycloheptadiene-5-yl]aminoheptanoate hydrochloride were obtained, of which a sample recrystallized from benzene gave a pure product melting instantaneously at 166°C to 168°C.
The hydrochloride of the crude ester obtained above was added to 25 ml of 2 N hydrochloric acid. The whole was kept under reflux for 2 hours. The material dissolved and a new hydrochloride then reprecipitated. After cooling, the hydrochloride of the crude acid was filtered off, washed with iced water and then recrystallized from distilled water. 5.7 g of 7- [dibenzo(a,d)cycloheptadienb-yl] aminoheptanoic acid hydrochloride were obtained, melting instantaneously at 226°C to 230°C.