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NOLADIN ETHER

NOLADIN ETHER 구조식 이미지

카스 번호:: 222723-55-9

상품명:: NOLADIN ETHER

동의어(영문):: HU 310;2-AG ETHER;Noladineether;NOLADIN ETHER;2-O-arachidonylglycerol;2-ARACHIDONYL GLYCEROL ETHER;2-ARACHIDONYL GLYCERYL ETHER;5Z,8Z,11Z,14Z-EICOSATETRAEN-2-GLYCERYL ETHER;2-[(5Z,8Z,11Z,14Z)-EICOSATETRAENYLOXY]-1,3-PROPANEDIOL;2-[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoxy]propane-1,3-diol

CBNumber:: CB8350967

분자식:: C23H40O3

포뮬러 무게:: 364.56

MOL 파일:: 222723-55-9.mol

속성

안전

용도

공급 업체 40

NOLADIN ETHER 속성

끓는 점: 488.9±45.0 °C(Predicted)

밀도: 0.948±0.06 g/cm3(Predicted)

인화점: 14℃

저장 조건: Desiccate at -20°C

용해도: DMF: 20 mg/ml; DMSO: 15 mg/ml; Ethanol: 25 mg/ml; Ethanol:PBS(pH 7.2) (1:1): 500 μg/ml

산도 계수 (pKa): 13.92±0.10(Predicted)

물리적 상태: 에탄올 용액(10mg/mL(1% w/v))

색상: 무색~연황색

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

위험품 표기	F
위험 카페고리 넘버	11
안전지침서	7-16
유엔번호(UN No.)	UN1170 - class 3 - PG 2 - Ethanol, solution
WGK 독일	2

그림문자(GHS):

신호 어:

Danger

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	그림 문자	P- 코드
H225	고인화성 액체 및 증기	인화성 액체	구분 2	위험		P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H319	눈에 심한 자극을 일으킴	심한 눈 손상 또는 자극성 물질	구분 2A	경고		P264, P280, P305+P351+P338,P337+P313P

예방조치문구:

P210	열·스파크·화염·고열로부터 멀리하시오 - 금연 하시오.
P305+P351+P338	눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

NFPA 704

	3
0		0

NOLADIN ETHER C화학적 특성, 용도, 생산

개요

2-Arachidonyl glycerol ether (2-AG ether) selectively binds to cannabinoid (CB) receptor 1 (K_is = 21.2 and >3,000 nM for CB₁ and CB₂, respectively, in a radioligand binding assay). It is a potent and selective agonist of CB₁ and GPR55 with EC₅₀ values of 10, 37, and >30,000 nM for CB₁, GPR55, and CB₂, respectively. 2-AG ether displays the typical tetrad of CB activities in mice. It is more chemically stable than 2-AG , with an endogenous half-life of hours rather than minutes. However, it is at least 10-fold less potent than 2-AG in eliciting typical CB₁-mediated responses. 2-AG ether elicits modest reductions in intraocular pressure in rabbits when administered at doses exceeding 50 μg per eye. It increases aqueous humor outflow via the CB₁ receptor in the trabecular meshwork. Administration of 2-AG ether to the nucleus accumbens (0.0625-1 μg) increases dietary intake and enhances fat consumption in rats given access to both high-carbohydrate and high-fat diets.

용도

HU 310 is an endogenous GPR55 and CB1 receptors agonist. HU 310 has been shown to induce hyperglycia in rats. HU 310 can be used to investigate the biological roles of GPR55 and CB1 receptors.

정의

ChEBI: A monoalkylglycerol that is the 2-O-arachidonyl derivative of glycerol.

생물학적 활성

Endogenous agonist for the GPR55 and CB 1 receptors (EC 50 values are 10 and 37 nM respectively) that displays selectivity over CB 2 receptors (K i values are 21.2 nM and > 3mM at CB 1 and CB 2 respectively). Causes sedation, hypothermia, intestinal immobility and mild antinociception in vivo . Attenuates sensory neurotransmission in rat mesenteric arteries via GPR55. Also available as part of the Endocannabinoid Tocriset™ .

NOLADIN ETHER 준비 용품 및 원자재

원자재

준비 용품

NOLADIN ETHER 공급 업체

글로벌( 40)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49739	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15848	69
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	United States	14059	65
EMMX Biotechnology LLC	888-539-0666	info@emmx.com	United States	8449	60
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9709	58
MedBioPharmaceutical Technology Inc	021-69568360 18916172912	order@med-bio.cn	China	8141	58
Meryer (Shanghai) Chemical Technology Co., Ltd.	18621169109	market03@meryer.com	China	27996	58
Nantong QuanYi Biotechnology Co., Ltd	0513-66337626 18051384581	sales@chemhifuture.com	China	4030	58

NOLADIN ETHER 관련 검색:

1-OCTADECANOYL-2-[(CIS,CIS,CIS,CIS)-5,8,11,14-EICOSATETRAENOYL]-SN-GLYCERO-3-PHOSPHOCHOLINE 1,2-DI5,8,11,14(ALL-CIS)EICOSATETRAENOYL-SN-GLYCERO-3-PHOSPHOCHOLINE 2-AG-D5 1-STEAROYL-2-ARACHIDONOYL-SN-GLYCEROL 2-AG 1-O-HEXADECYL-2-ARACHIDONYL-SN-GLYCERO-3-PHOSPHOCHOLINE 2-AG-D8 NOLADIN ETHER 1-STEAROYL-2-ARACHIDONOYL-PHOSPHATIDYLINOSITOL 3,4,5-TRIPHOSPHATE, (NA+ SALT) TRIARACHIDONIN PHOSPHATIDYLCHOLINE, L-ALPHA-1-STEAROYL-2-ARACHIDONYL, [ARACHIDONYL-5,6,8,9,11,12,14,15-3H(N)] 2-ARACHIDONYL GLYCEROL [ARACHIDONYL 5,6,8,9,11,12,14,15-3H(N)] 3-STERAOYL-2-ARACHIDONYL-SN-GLYCEROL PHOSPHATIDYLCHOLINE, L-ALPHA-1-PALMITOYL-, 2-ARACHIDONYL, [ARACHIDONYL-1-14C] PHOSPHATIDYLCHOLINE, L-ALPHA-1-O HEXADECYL-1-2-ARACHIDONYL, [ARACHIDONYL-5,6,8,9,11,12,14,15-3H(N)] PHOSPHATIDYLETHANOLAMINE, L-ALPHA-1-PALMITOYL, 2-ARACHIDONYL, [ARACHIDONYL-1-14C] 1-STEAROYL-2-[1-14C]ARACHIDONYL-SN-GLYCEROL L-3-PHOSPHATIDYLCHOLINE,1-STEAROYL-2-[1-14C]ARACHIDONYL