indicine-N-oxide

indicine-N-oxide 구조식 이미지
카스 번호:
41708-76-3
상품명:
indicine-N-oxide
동의어(영문):
NSC132319;Indicin-N-oxid;indicine-N-oxide;(+)-Indicine N-oxide;DNAWGBOKUFFVMB-PZIGJSDBSA-N;(7R,8R)-7-hydroxy-4-oxido-5,6,7,8-tetrahydro-3H-pyrrolizin-4-ium-1-yl]methyl (2R)-2-hydroxy-2-[(1S)-1-hydroxyethyl]-3-methylbutanoate;Butanoic acid, 2,3-dihydroxy-2-(1-methylethyl)-, [(1R,7aS)-2,3,5,7a-tetrahydro-1-hydroxy-4-oxido-1H-pyrrolizin-7-yl]methyl ester, (2R,3S)-
CBNumber:
CB91364920
분자식:
C15H25NO6
포뮬러 무게:
315.36
MOL 파일:
41708-76-3.mol

indicine-N-oxide 속성

녹는점
130.5°C (rough estimate)
끓는 점
454.91°C (rough estimate)
밀도
1.1359 (rough estimate)
굴절률
1.5000 (estimate)
산도 계수 (pKa)
12.54±0.29(Predicted)

안전

유엔번호(UN No.) 1544
위험 등급 6.1(b)
포장분류 III

indicine-N-oxide C화학적 특성, 용도, 생산

개요

Heliotropiurn indicurn also contains this base which has the structure given above based upon comparison with the preceding alkaloid. The base has proved to be highly active against transplanted neoplasts, Walker-256 carcinosarcoma, melanoma B-16, leukaemia L-12l 0, leukaemia P-388 and leukaemia P-1534 in mice and rats, giving up to 91 per cent inhibition of transplanted growth at a daily dosage of 200 mgm. per kilo.

용도

Indicine N-oxide is a pyrrolizidine alkaloid that is isolated from Heliotropium indicum, one of the most widely used herbs in India. Indicine N-oxide exhibits antitumour and antimitotic activity in humans, and has subsequently undergone Phase I & II trials in adults and children with leukemia and solid tumours.

참고 문헌

Rao, McBride., U.S. Patent, 3,717,710 February 20,1973

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준비 용품


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