Gap19

Gap19 구조식 이미지
카스 번호:
1507930-57-5
상품명:
Gap19
동의어(영문):
Gap19;KQIEIKKFK;L-Lysine, L-lysyl-L-glutaminyl-L-isoleucyl-L-α-glutamyl-L-isoleucyl-L-lysyl-L-lysyl-L-phenylalanyl-;myocardial,Gap19,cytoplasmic,Cx40/pannexin-1,inhibit,Gap Junction Protein,C-terminus,Gap 19,hemichannel,Inhibitor,loop,Gap-19,Cx43,channels,connexin
CBNumber:
CB94632530
분자식:
C55H96N14O13
포뮬러 무게:
1161.46
MOL 파일:
1507930-57-5.mol
MSDS 파일:
SDS

Gap19 속성

끓는 점
1511.4±65.0 °C(Predicted)
밀도
1.212±0.06 g/cm3(Predicted)
저장 조건
-20°C
용해도
≥58.07 mg/mL in H2O; insoluble in EtOH; ≥26.55 mg/mL in DMSO
물리적 상태
가루
산도 계수 (pKa)
3.30±0.10(Predicted)
색상
흰색에서 황백색까지
수용성
물에 2mg/ml까지 용해됨

안전

Gap19 C화학적 특성, 용도, 생산

용도

Gap19 is a short peptide that inhibits hemichannels specifically for connexin-43 (Cx43), a cardiac connexin involved with gap junction formation. Gap junctions facilitate the exchange of ions and metabolites between cytoplasm and extracellular milieu. Reagents that inhibit hemichannels may have cardioprotective properties.

Biochem/physiol Actions

Gap19, nonapeptide from the cytoplasmic loop of Connexin-43, is a selective blocker of connexin 43 (Cx43) hemichannel that does not block GJ or Cx40/Panx-1 channels in cardiomyocytes and astrocytes. Gap19 prevents Cx43 hemichannel opening and protect against myocardial ischemia/reperfusion injury.

Gap19 준비 용품 및 원자재

원자재

준비 용품


Gap19 공급 업체

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