1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE manufacturers and suppliers

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE suppliers

Properties

Melting point:: aprox. 36°C

Boiling point:: 128-132 °C12 mm Hg(lit.)

Density: 1.001±0.06 g/cm3(Predicted)

storage temp.: Inert atmosphere,Room Temperature

solubility: Chloroform (Slightly), Dichloromethane (Slightly), Ethyl Acetate (Slightly)

form: Solid

pka: 8.66±0.40(Predicted)

color: Pale Yellow to Light Yellow

Merck: 13,6319

Stability:: Stable. Incompatible with strong oxidizing agents.

Safety Information

Symbol(GHS): GHS08,GHS06

Signal word: Danger

Hazard statements: H370-H301

Precautionary statements: P264-P270-P301+P310-P321-P330-P405-P501-P260-P264-P270-P307+P311-P321-P405-P501

Hazard Codes: T

Risk Statements: 25-39/23/24/25

Safety Statements: 45

RIDADR: UN 2811 6.1/PG 2

WGK Germany: 3

RTECS: UT8358900

HazardClass: 6.1(b)

PackingGroup: III

Hazardous Substances Data: 28289-54-5(Hazardous Substances Data)

Toxicity: Human toxicity originally discovered when it was an unexpected by-product from the illicit synthesis of a heroin substitute (i.e., meperidine analog). Currently used experimentally as the primary animal model for the study of Parkinson’s disease. MPTP is a neurotoxicant that is activated to 1-methyl-4-phenylpyridinium ion (MPP1) by the actions of monoamine oxidase B located in the mitochondria of brain astrocytes. The MPP1 is then transported into dopamine, and to a lesser extent, other monoaminergic neurons. Once inside these dopamine neurons in the substantia nigra, it destroys these neurons by mechanisms that may involve an oxidative cascade and/or inhibition of electron transport. Intoxication causes a parkinsonism syndrome almost identical in signs and symptoms to Parkinson’s disease, including rigidity, bradykinesia, tremor, and postural instability. In the event of known ingestion, immediate (but not delayed) administration of a monoamine oxidase inhibitor (especially one selective for MAO-B like deprenyl) and dopamine uptake inhibitor can be therapeutic.

Use

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine is a dopaminergic neurotoxin that reportedly causes a severe and irreversible Parkinsonian condition in humans and monkeys.

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