2,6-Dichlorothiobenzamide manufacturers and suppliers

2,6-Dichlorothiobenzamide suppliers

Properties

Melting point:: 151-152°C

Boiling point:: 320.6±52.0 °C(Predicted)

Density: 1.4704 (rough estimate)

refractive index: 1.6300 (estimate)

Flash point:: >100 °C

storage temp.: -20°C Freezer, Under inert atmosphere

solubility: DMSO (Slightly), Methanol (Slightly)

pka: 11.71±0.29(Predicted)

color: White to Pale Beige

Water Solubility: 0.95g/L(21 ºC)

BRN: 1910353

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H302

Precautionary statements: P264-P270-P301+P312-P501

Hazard Codes: Xn

Risk Statements: 22

Safety Statements: 36

WGK Germany: 1

RTECS: CV3850000

Hazard Note: Harmful

HazardClass: IRRITANT

HS Code: 2930909899

Toxicity: LD50 oral in rabbit: 300mg/kg

Use

Twelve metabolites are isolated from either urine or bile from either rats (11 metabolites) or goats (seven metabolites) given single oral doses of 14C-labeled 2,6-dichlorobenzonitrile (DCBN). Five of these metabolites are also excreted in urine from rats dosed orally with 2,6-dichlorothiobenzamide (DCTBA) which is an acid amide analog. All metabolites from either DCBN or DCTBA are benzonitriles with the following ring substituents: Cl2, OH (three isomers); Cl2, (OH)2; Cl, (OH)2; Cl, OH, SH; Cl, OH, SCH3; SOCH3, OH; Cl2, S-(N-acetyl)cysteine; Cl, S-(N-acetyl)cysteine; Cl, OH, S-(N-acetyl)cysteine. The thiobenzamide moiety of DCTBA is converted to the nitrile in all extracted urinary metabolites. No hydrolysis of the nitrile in DCBN to either amide or an acid is detected. Urine is the major route for excretion; however, enterohepatic circulation occurs.

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