3,3',5-Triiodo-L-thyronine manufacturers and suppliers

3,3',5-Triiodo-L-thyronine suppliers

Properties

Melting point:: 234-238 °C(lit.)

alpha: 23 º (c=2 in ethanol)

Boiling point:: 232°C (rough estimate)

Density: 2.2155 (estimate)

Flash point:: 9°C

storage temp.: -20°C

solubility: DMSO (Slightly), Methanol (Very Slightly)

form: powder

pka: pKa 8.5 (Uncertain);8.4 (Uncertain);8.45 (Uncertain)

color: Off-white to pale yellow

optical activity: [α]25/D +23.0°, c = 2 in 1 N HCl: ethanol, 1:2

Water Solubility: Insoluble in water, ethanol and propylene glycol. Soluble in dilute alkalies.

Sensitive: Light Sensitive

Merck: 14,5510

BRN: 2710227

Stability:: Light Sensitive

Safety Information

Symbol(GHS): GHS07

Signal word: Danger

Hazard statements: H315-H319-H335

Precautionary statements: P261-P280a-P304+P340-P305+P351+P338-P405-P501a

Hazard Codes: Xn,Xi,T,F

Risk Statements: 20/21/22-36/37/38-39/23/24/25-23/24/25-11

Safety Statements: 36-26-36/37/39-45-36/37-16

RIDADR: UN1230 - class 3 - PG 2 - Methanol, solution

WGK Germany: 3

RTECS: AY6750000

F: 8

HS Code: 29225090

Toxicity: LDLo oral in rat: 7500mg/kg

Use

3,3',5-Triiodo-L-thyronine (T3) is a thyroid hormone.It is produced by 5'-monodeiodination of the prohormone thyroxine (T4) in various tissues, including liver and kidney. T3 is an agonist of thyroid hormone receptors TRα and TRβ (Kis = 2.3 nM for both) that modulates diverse biological properties, including metabolism, cardiac function, growth, and redox signaling.It also functions as an inhibitor of L-type amino acid transporter 1 (LAT1), inhibiting LAT1-mediated leucine uptake in HEK293 cells when used at a concentration of 10 μM.

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