4-Aminosalicylic acid manufacturers and suppliers

4-Aminosalicylic acid suppliers

Properties

Melting point:: 135-145 °C (lit.)

Boiling point:: 276.03°C (rough estimate)

Density: 1.3585 (rough estimate)

refractive index: 1.5500 (estimate)

storage temp.: Keep in dark place,Inert atmosphere,Room temperature

solubility: 1.69g/l

form: Powder

pka: 3.25(at 25℃)

color: Colorless

PH: 3.5 (1g/l, H2O, 20℃)

Water Solubility: 2 g/L (20 ºC)

Merck: 14,477

BRN: 473071

BCS Class: 4/2

Stability:: Hygroscopic

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H319-H335-H315

Precautionary statements: P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P280a-P304+P340-P405-P501a-P305+P351+P338

Hazard Codes: Xn,Xi,T

Risk Statements: 22-36-36/37/38-45-35-61

Safety Statements: 26-37/39-45-53-36-36/37/39

RIDADR: UN 1789 8/PG 3

WGK Germany: 2

RTECS: VO1225000

TSCA: Yes

HS Code: 29225000

Toxicity: LD50 orally in mice: 4 g/kg (Bavin)

Use

4-Aminosalicylic acid occurs as a white to yellowish white crystalline solid that darkens on exposure to light or air. It is slightly soluble in water but more soluble in alcohol. Alkali metal salts and the nitric acid salt are soluble in water, but the salts of hydrochloric acid and sulfuric acid are not. The acid undergoes decarboxylation when heated. An aqueous solution has a pH of approximately 3.2. PAS is administered orally in the form of the sodium salt, usually in tablet or capsule form. Symptoms of gastrointestinal irritation are common with both the acid and the sodium salt. Various enteric-coated dosage forms have been used in an attempt to overcome this disadvantage. Other forms that are claimed to improve gastrointestinal tolerance include the calcium salt, the phenyl ester, and a combination with an anion exchange resin (Rezi-PAS). An antacid such as aluminum hydroxide is frequently prescribed. The oral absorption of PAS is rapid and nearly complete, and it is widely distributed into most of the body fluids and tissues, with the exception of the CSF, in which levels are significantly lower.It is excreted primarily in the urine as both unchanged drug and metabolites.

You can find 4-Aminosalicylic acid suppliers, manufacturers, and distributors from countries such as China, United States and the India here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.