6-Thioguanine manufacturers and suppliers

6-Thioguanine suppliers

Properties

Melting point:: ≥300 °C(lit.)

Density: 1.483 (estimate)

refractive index: 1.5605 (estimate)

storage temp.: 2-8°C

solubility: Practically insoluble in water and in ethanol (96%). It dissolves in dilute solutions of alkali hydroxides.

form: lyophilized powder

pka: pKa 8.22 (Uncertain)

Boiling point:: 555.4±42.0 °C(Predicted)

color: Yellow to green

Water Solubility: soluble

Merck: 14,9337

BRN: 157765

Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMF may be stored at -20°C for up to 1 month.

Safety Information

Symbol(GHS): GHS06

Signal word: Danger

Hazard statements: H301

Precautionary statements: P301+P310

Hazard Codes: T,Xi

Risk Statements: 25-23/24/25

Safety Statements: 28-36/37/39-45-28A

RIDADR: UN 2811 6.1/PG 3

WGK Germany: 3

RTECS: UP0740000

F: 13

Hazard Note: Irritant

HazardClass: 6.1

PackingGroup: III

HS Code: 29335990

Toxicity: LD50 oral in mouse: 160mg/kg

Use

6-Thioguanine is a purine analogue structurally related to 6-mercaptopurine and azathioprine. Thioguanine interferes with several enzymes required for de novo purine synthesis, and its metabolites are incorporated into DNA and RNA, further impeding nucleic acid synthesis. The mechanism of action of thioguanine in psoriasis is not clearly understood; it has been hypothesized to affect the proliferation and trafficking of lymphocytes as well as the proliferation of keratinocytes.

You can find 6-Thioguanine suppliers, manufacturers, and distributors from countries such as China, United States and the United Kingdom here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.