7α,25-dihydroxy Cholesterol manufacturers and suppliers

7α,25-dihydroxy Cholesterol suppliers

7α,25-dihydroxy Cholesterol

CAS:: 64907-22-8

MF:: C27H46O3

MW:: 418.65

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Properties

Boiling point:: 548.5±35.0 °C(Predicted)

Density: 1.08±0.1 g/cm3(Predicted)

storage temp.: 2-8°C

solubility: DMSO: soluble5mg/mL (clear solution)

form: powder

pka: 14.11±0.70(Predicted)

color: white to beige

Safety Information

Hazard statements: H413

Precautionary statements: P273-P501

WGK Germany: 3

Use

GPR183 (also known as Epstein-Barr virus-induced gene 2) is an orphan G protein-coupled receptor (GPCR) that is highly expressed in spleen and is required for humoral immune responses, including B cell migration and T cell-dependent antibody production. 7α,25-dihydroxy Cholesterol (7α,25-DHC) is a potent agonist of GPR183 that induces specific activation of the receptor with an EC50 value of 50 nM (Kd = 450 pM). At concentrations below 3 μM, it does not show any appreciable binding activity when tested against eight different nuclear hormone receptors including LXR and thirty-one different G protein-coupled receptors in a panel of reporter gene assays. 7α,25-DHC can act as a potent chemokine, affecting migration of immune cells expressing GPR183 both in vitro (EC50 = 500 pM) and in vivo.[Cayman Chemical]

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