9-keto Fluprostenol isopropyl ester manufacturers and suppliers

9-keto Fluprostenol isopropyl ester suppliers

9-keto Fluprostenol isopropyl ester

CAS:: 1219032-18-4

MF:: C26H33F3O6

MW:: 498.53

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Properties

Boiling point:: 583.6±50.0 °C(Predicted)

Density: 1.241±0.06 g/cm3(Predicted)

solubility: DMF: 30 mg/ml; DMF:PBS (1:1): 500 μg/ml; DMSO: 20 mg/ml; Ethanol: 25 mg/ml

pka: 13.32±0.20(Predicted)

Safety Information

Symbol(GHS): GHS02,GHS07

Signal word: Danger

Hazard statements: H225-H319

Precautionary statements: P210-P233-P240-P241-P242-P243-P264-P280-P303+P361+P353-P305+P351+P338-P337+P313-P370+P378-P403+P235-P501

Use

Fluprostenol is a well-studied, potent analog of prostaglandin F2α (PGF2α) and acts primarily through the FP receptor. 9-keto Fluprostenol is an analog of PGE2 with structural modifications intended to give it a prolonged half-life and greater potency. 9-keto Fluprostenol isopropyl ester has the potential to act as an EP agonist in prodrug form. However, no studies on the pharmacology of this compound have been published to date. In addition 9-keto fluprostenol isopropyl ester is a potential metabolite of Travoprost, which is the Alcon trade name for fluprostenol isopropyl ester. In monkey cornea, this transformation was observed as a product of NADP+-dependent 15-hydroxyprostaglandin dehydrogenase when the closely related analog Latanoprost was used as a substrate. Certain F-series prostaglandins have been shown to be converted to the corresponding E-series compounds in rabbit liver and human platelet preparations.

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