Blonanserin manufacturers and suppliers

Blonanserin suppliers

Properties

Melting point:: 117-119°C

Boiling point:: 540.8±50.0 °C(Predicted)

Density: 1.095±0.06 g/cm3(Predicted)

storage temp.: Sealed in dry,Room Temperature

solubility: DMSO: ≥10mg/mL

form: powder

pka: 7.66±0.10(Predicted)

color: white to off-white

Merck: 14,1319

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H302-H413

Precautionary statements: P273-P301+P312+P330

Hazard Codes: Xn

Risk Statements: 22

WGK Germany: 1

RTECS: GY0175140

HS Code: 29339900

Toxicity: mouse,LD,oral,> 500mg/kg (500mg/kg),United States Patent Document. Vol. #5021421,

Use

Blonanserin, a dual antagonist of dopamine D2 and serotonin 5-HT2 receptors, was launched past year in Japan for the oral treatment of psychosis and schizophrenia. It is the latest entry in the class of atypical antipsychotic agents to reach the market. Blonanserin exhibits high affinity for D2 and 5-HT2 receptors (IC50 23.6 and 9.85 nM, respectively). Its affinity for D2 receptors is very close to that of haloperidol and risperidone, whereas the affinity for 5-HT2 receptors is about 7 times higher than that of haloperidol and 10 times lower than that of risperidone.Blonanserin is chemically derived in three steps starting with a polyphosphoric acid mediated condensation reaction of cyclooctanone with 4-fluorobenzoylacetonitrile. The resultant 4-fluorophenylcycloocta[b]pyridin-2-one intermediate is converted to the corresponding 2-chloro derivative by treatment with phosphoryl chloride and subsequently condensed with 1-ethylpiperazine to afford blonanserin.

You can find Blonanserin suppliers, manufacturers, and distributors from countries such as China, United States and the India here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.